Immunohistochemical expression of MMP-9 and VEGF in squamous cell carcinoma of the tongue

Squamous cell carcinomas (SCCs) account for approximately 95% of all oral malignant neoplasms and for about 38% of all malignant head and neck tumors, especially affecting the tongue and lips. The aim of this study was to evaluate the immunohistochemical expression of MMP-9 and VEGF in oral SCC acco...

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Bibliographic Details
Published in:Journal of Oral Science 2012, Vol.54(1), pp.105-111
Main Authors: Henriques, Águida Cristina G., Matos, Felipe R. de, Galvão, Hébel C., Freitas, Roseana de A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - blood supply
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - secondary
Dentistry
Female
Humans
Immunoenzyme Techniques
immunohistochemistry
Male
Matrix Metalloproteinase 9 - biosynthesis
Matrix Metalloproteinase 9 - genetics
Middle Aged
MMP-9
Neoplasm Metastasis
Neovascularization, Pathologic
oral squamous cell carcinoma
Paraffin Embedding
Retrospective Studies
Statistics, Nonparametric
Stromal Cells - metabolism
Tongue Neoplasms - blood supply
Tongue Neoplasms - metabolism
Tongue Neoplasms - secondary
Vascular Endothelial Growth Factor A - biosynthesis
Vascular Endothelial Growth Factor A - genetics
VEGF
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Summary:Squamous cell carcinomas (SCCs) account for approximately 95% of all oral malignant neoplasms and for about 38% of all malignant head and neck tumors, especially affecting the tongue and lips. The aim of this study was to evaluate the immunohistochemical expression of MMP-9 and VEGF in oral SCC according to the occurrence of metastasis. Eighteen cases of tongue SCC without metastases and 17 cases of tongue SCC with metastases were subjected to immunohistochemical methods. High immunohistochemical expression of MMP-9 and VEGF by neoplastic cells and stroma was observed in tongue SCCs at the invasion front. Metastatic tumors tended to express higher levels of MMP-9 and VEGF than non-metastatic tumors, but the difference was not significant (P > 0.05). Spearman’s correlation test showed no significant correlation between VEGF-immunopositive vessels and metastasis (P > 0.05). The present results demonstrate the importance of the expression of MMP-9 and VEGF for the development of SCC of the tongue. However, no significant association was observed between the overexpression of MMP-9 or VEGF and the presence of metastases. (J Ora Sci 54, 105-111, 2012)
ISSN:1343-4934
1880-4926
DOI:10.2334/josnusd.54.105