Thermoanalytical study of some anti-inflammatory analgesic agents

Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC) as well as X-ray diffraction powder (DRX) patterns and Fourier transformed infrared spectroscopy (FTIR) were used to study ketoprofen, ibuprofen, and naproxen. The chemical or physical properties of t...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2010-10, Vol.102 (1), p.163-170
Main Authors: Bannach, G., Arcaro, R., Ferroni, D. C., Siqueira, A. B., Treu-Filho, O., Ionashiro, M., Schnitzler, E.
Format: Article
Language:English
Subjects:
Analgesics
Analysis
Analytical Chemistry
Anti-inflammatory drugs
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Calorimetry
Chemistry
Chemistry and Materials Science
Differential scanning calorimetry
Differential thermal analysis
Diffraction
Ibuprofen
Infrared spectroscopy
Inorganic Chemistry
Mathematical analysis
Measurement Science and Instrumentation
Medical sciences
Neuropharmacology
Nonsteroidal anti-inflammatory drugs
Pharmacology. Drug treatments
Physical Chemistry
Polymer Sciences
Quantum chemistry
X-rays
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Summary:Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC) as well as X-ray diffraction powder (DRX) patterns and Fourier transformed infrared spectroscopy (FTIR) were used to study ketoprofen, ibuprofen, and naproxen. The chemical or physical properties of the studied compounds were established and when possible by X-ray powder diffractometry and/or infrared spectroscopy were used. In this investigation, quantum chemical approach was used to determine the molecular structures using Becke three-parameter hybrid method and the Lee–Yang–Par (LYP) correlation functional. The performed molecular calculations in this work were done using the Gaussian 03 routine. Theoretical calculations help in interpretations of FTIR spectra supplying structural and physicochemical parameters.
ISSN:1388-6150
1588-2926
1572-8943
DOI:10.1007/s10973-010-0939-x