Thermal analysis of prednicarbate and characterization of thermal decomposition product

In the present work, the thermal behavior of prednicarbate was studied using DSC and TG/DTG. The solid product remaining at the first decomposition step of the drug was isolated by TG, in air and N 2 atmospheres and was characterized using LC-MS/MS, NMR, and IR spectroscopy. It was found that the pr...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2010-10, Vol.102 (1), p.277-283
Main Authors: Salvio Neto, Hélio, Barros, Fábio Alessandro Proença, de Sousa Carvalho, Flávio Machado, Matos, Jivaldo Rosário
Format: Article
Language:English
Subjects:
Analysis
Analytical Chemistry
Biological and medical sciences
Bonding
Calorimetry
Carbonates
Chemical properties
Chemistry
Chemistry and Materials Science
Chromatographic methods and physical methods associated with chromatography
Differential scanning calorimetry
Exact sciences and technology
General pharmacology
Infrared radiation
Inorganic Chemistry
Measurement Science and Instrumentation
Medical sciences
Nuclear magnetic resonance spectroscopy
Other chromatographic methods
Pharmacology. Drug treatments
Physical Chemistry
Polymer Sciences
Spectra
Thermal analysis
Thermal decomposition
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Summary:In the present work, the thermal behavior of prednicarbate was studied using DSC and TG/DTG. The solid product remaining at the first decomposition step of the drug was isolated by TG, in air and N 2 atmospheres and was characterized using LC-MS/MS, NMR, and IR spectroscopy. It was found that the product at the first thermal decomposition step of prednicarbate corresponds to the elimination of the carbonate group bonding to C 17 , and a consequent formation of double bond between C 17 and C 16 . Structure elucidation of this degradation product by spectral data has been discussed in detail.
ISSN:1388-6150
1588-2926
1572-8943
DOI:10.1007/s10973-009-0419-3