Design and Transdermal Delivery of Indomethacin Nanosystem

• Published in: Journal of materials science and engineering. A 2011-09, Vol.1 (4), p.531-537
• Main Authors: Reis, C P, de Freitas Nunes, F, Rosado, C, Rodrigues, L
• Format: Article
• Language: chi ; eng
• Subjects: Drugs; Encapsulation; Nanocomposites; Nanomaterials; Nanoparticles; Nanostructure; Permeation; Zeta potential; zeta电位; 吲哚美辛; 平均粒径; 纳米粒子; 纳米系统; 设计; 透皮给药
• ISSN: 2161-6213

Transdermal drug delivery is one of the most promising routes of drug administration. The aim of this study was to apply nanoencapsulation technologies in order to enhance bioavailability and reduce toxicity of indomethacin after transdermal administration. Methods： Nanoparticles were produced by a two-step desolvation process. Parameters such as mean particle size, zeta potential and encapsulation efficiency were studied. A model drug was selected for encapsulation-indomethacin. The permeability of free-indomethacin in a cellulose-based vehicle and that of indomethacin-loaded nanoparticles was investigated using Franz diffusion cells. The cumulative amount of indomethacin that diffused across a model membrane was measured and the steady-state fluxes of the permeant in the different systems were determined. Results： This study showed that it is possible to prepare indomethacin-loaded gelatine nanoparticles with small particle size （mean size lower than 350 nm） with polydispersivity index ranging from 0.125 to 0.199 and negative zeta potential. Encapsulation efficiency was around 70%. Permeation studies showed that nanoparticles prolonged indomethacin release. In conclusion, the present data confirm the feasibility of developing indomethacin transdermal nanosystems on an industrial scale. Further studies, now in progress, will deal with the application of the presently reported findings to human skin permeation, involving both in vitro and in vivo testing.