Ferroceneboronic acid for the electrochemical probing of interactions involving sugars

Ferroceneboronic acid (FcBA) was used as a redox-active probe suitable for monitoring of diol–boronate interactions. Voltammetric and amperometric measurements allowed to detect FcBA forms – free and bound in the boronate complex. In this way, the complexation interaction was studied for a set of sa...

Full description

Saved in:
Bibliographic Details
Published in:Electrochimica acta 2011-11, Vol.56 (27), p.10246-10252
Main Authors: Lacina, Karel, Skládal, Petr
Format: Article
Language:English
Subjects:
Affinity
Analytical chemistry
Biotechnology
Boronate complex
Boronic acid
Chemically modified electrode
Chemistry
Complexation
Conjugates
Deposition
Diols
Electrochemical methods
Electrochemistry
Electrodes
Electrodes: preparations and properties
Exact sciences and technology
Ferrocene
General and physical chemistry
Monitoring
Other electrodes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ferroceneboronic acid (FcBA) was used as a redox-active probe suitable for monitoring of diol–boronate interactions. Voltammetric and amperometric measurements allowed to detect FcBA forms – free and bound in the boronate complex. In this way, the complexation interaction was studied for a set of saccharide molecules as model diols and the corresponding affinity equilibrium constants were determined. A shift of the peak potential on voltammograms accompanying formation of the boronate complex with FcBA was proposed as a probe for electrochemical characterization of surface-confined diol-containing structures. The model experiments were carried out using sorbitol- and 1,6-hexandiol-modified polyepichlorhydrin conjugates deposited on the electrodes; the former compound was able to form the boronate complex while no change of the peak potential for the latter conjugate was observed. This approach seems promising for artificial bioelectronic affinity receptors and technology of reagentless biosensors where the binding interaction directly stimulates a measurable electrochemical event.
ISSN:0013-4686
1873-3859
DOI:10.1016/j.electacta.2011.09.019