Glassy carbon electrode modified with a bilayer of multi-walled carbon nanotube and polypyrrole doped with new coccine: Application to the sensitive electrochemical determination of Sumatriptan

A promising electrochemical sensor was developed based on a layer by layer process by electro-polymerization of pyrrole in the presence of new coccine (NC) as dopant anion on the surface of the multi-walled carbon nanotubes (MWCNTs) pre-coated glassy carbon electrode (GCE). The modified electrode wa...

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Bibliographic Details
Published in:Electrochimica acta 2011-11, Vol.56 (27), p.10032-10038
Main Authors: Shahrokhian, Saeed, Kamalzadeh, Zahra, Saberi, Reyhaneh-Sadat
Format: Article
Language:English
Subjects:
Analysis
Anions
Biological and medical sciences
Drop size
Electrodes
General pharmacology
Glassy carbon
Medical sciences
Modified electrode
Multi wall carbon nanotubes
Multi-walled carbon nanotubes
New coccine
Numerical control
Pharmacology. Drug treatments
Polypyrrole
Pyrroles
Sensors
Sumatriptan
Voltammetry
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Summary:A promising electrochemical sensor was developed based on a layer by layer process by electro-polymerization of pyrrole in the presence of new coccine (NC) as dopant anion on the surface of the multi-walled carbon nanotubes (MWCNTs) pre-coated glassy carbon electrode (GCE). The modified electrode was used as a new and sensitive electrochemical sensor for voltammetric determination of sumatriptan (SUM). The electrochemical behavior of SUM was investigated on the surface of the modified electrode using linear sweep voltammetry (LSV). The results showed a remarkable increase (∼12 times) in the anodic peak current of SUM in comparison to the bare GCE. The effect of experimental variables such as, drop size of the casted MWCNTs suspension, pH of the supporting electrolyte, accumulation conditions and the number of cycles in the electro-polymerization process on the electrode response was investigated. Under the optimum conditions, the modified electrode showed a wide linear dynamic range of 0.02–10.0μmolL−1 with a detection limit of 6nmolL−1 for the voltammetric determination of SUM. The prepared electrode showed high sensitivity, stability and good reproducibility in response to SUM. This sensor was successfully applied for the accurate determination of trace amounts of SUM in pharmaceutical and clinical preparations.
ISSN:0013-4686
1873-3859
DOI:10.1016/j.electacta.2011.08.102