Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene

We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized h...

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Bibliographic Details
Published in:Nanoscale 2011-01, Vol.3 (6), p.2461-2464
Main Authors: Sasidharan, Abhilash, Panchakarla, L S, Chandran, Parwathy, Menon, Deepthy, Nair, Shantikumar, Rao, C N R, Koyakutty, Manzoor
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cell Survival - drug effects
Cercopithecus aethiops
Flow Cytometry
Graphene
Graphite - chemistry
Graphite - toxicity
Hydrophobic and Hydrophilic Interactions
Materials Testing
Membranes
Microscopy, Confocal
Nanocomposites
Nanomaterials
Nanostructure
Nanostructures - chemistry
Nanostructures - toxicity
Oxidative Stress - drug effects
Toxicity
Toxicity Tests
Toxicology
Vero Cells
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Summary:We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.
ISSN:2040-3364
2040-3372
DOI:10.1039/c1nr10172b