Live-cell monitoring of the glutathione-triggered release of the anticancer drug topotecan on gold nanoparticles in serum-containing media

The intracellular glutathione-triggered release of the anticancer drug topotecan from gold nanoparticles in serum-containing media was directly monitored in real time using a label-free fluorescence live-cell imaging technique.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-05, Vol.48 (35), p.4205-4207
Main Authors: Kim, Mira, Ock, Kwangsu, Cho, Keunchang, Joo, Sang-Woo, Lee, So Yeong
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - metabolism
Antineoplastic Agents - therapeutic use
Antitumor agents
Cell Line, Tumor
Culture Media
Glutathione - chemistry
Glutathione - metabolism
Gold - chemistry
Humans
Metal Nanoparticles - chemistry
Mice
Microscopy, Confocal
Neoplasms - drug therapy
Topotecan - metabolism
Topotecan - therapeutic use
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Description
Summary:The intracellular glutathione-triggered release of the anticancer drug topotecan from gold nanoparticles in serum-containing media was directly monitored in real time using a label-free fluorescence live-cell imaging technique.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc30679d