Live-cell monitoring of the glutathione-triggered release of the anticancer drug topotecan on gold nanoparticles in serum-containing media

The intracellular glutathione-triggered release of the anticancer drug topotecan from gold nanoparticles in serum-containing media was directly monitored in real time using a label-free fluorescence live-cell imaging technique.

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Published in:Chemical communications (Cambridge, England) England), 2012-05, Vol.48 (35), p.4205-4207
Main Authors: Kim, Mira, Ock, Kwangsu, Cho, Keunchang, Joo, Sang-Woo, Lee, So Yeong
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - metabolism
Antineoplastic Agents - therapeutic use
Antitumor agents
Cell Line, Tumor
Culture Media
Glutathione - chemistry
Glutathione - metabolism
Gold - chemistry
Humans
Metal Nanoparticles - chemistry
Mice
Microscopy, Confocal
Neoplasms - drug therapy
Topotecan - metabolism
Topotecan - therapeutic use
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cited_by cdi_FETCH-LOGICAL-c319t-935783eacb2457bad46db7b9f439a6cf8db8526ef00724b70d529ca69b635cfd3
cites cdi_FETCH-LOGICAL-c319t-935783eacb2457bad46db7b9f439a6cf8db8526ef00724b70d529ca69b635cfd3
container_end_page 4207
container_issue 35
container_start_page 4205
container_title Chemical communications (Cambridge, England)
container_volume 48
creator Kim, Mira
Ock, Kwangsu
Cho, Keunchang
Joo, Sang-Woo
Lee, So Yeong
description The intracellular glutathione-triggered release of the anticancer drug topotecan from gold nanoparticles in serum-containing media was directly monitored in real time using a label-free fluorescence live-cell imaging technique.
doi_str_mv 10.1039/c2cc30679d
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source Royal Society of Chemistry
subjects Animals
Antineoplastic Agents - metabolism
Antineoplastic Agents - therapeutic use
Antitumor agents
Cell Line, Tumor
Culture Media
Glutathione - chemistry
Glutathione - metabolism
Gold - chemistry
Humans
Metal Nanoparticles - chemistry
Mice
Microscopy, Confocal
Neoplasms - drug therapy
Topotecan - metabolism
Topotecan - therapeutic use
title Live-cell monitoring of the glutathione-triggered release of the anticancer drug topotecan on gold nanoparticles in serum-containing media
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