Impact of biocides on biofilm formation by methicillin-resistant Staphylococcus aureus (ST239-SCCmecIII) isolates

ABSTRACT Procedures of sterilization and disinfection are essential to ensure that medical and surgical instruments will not transmit infectious pathogens to patients. In the present paper, we tested the residual effect of these compounds on biofilm formation and its efficiency in disrupting preform...

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Bibliographic Details
Published in:Microbiology and immunology 2012-03, Vol.56 (3), p.203-207
Main Authors: Aparecida Guimarães, Marcia, Rocchetto Coelho, Leonardo, Rodrigues Souza, Raquel, Ferreira-Carvalho, Bernadete Teixeira, Marie Sá Figueiredo, Agnes
Format: Article
Language:English
Subjects:
biocide
biofilm
Biofilms - drug effects
Biofilms - growth & development
Disinfectants - pharmacology
Disinfection - methods
Humans
methicillin-resistant Staphylococcus aureus (MRSA)
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - physiology
ST239
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Summary:ABSTRACT Procedures of sterilization and disinfection are essential to ensure that medical and surgical instruments will not transmit infectious pathogens to patients. In the present paper, we tested the residual effect of these compounds on biofilm formation and its efficiency in disrupting preformed biofilms using methicillin‐resistant Staphylococcus aureus (MRSA) isolates of the lineage ST239‐SCCmecIII. All compounds examined, except 70% alcohol, caused a significant impairment in biofilm formation with concomitant inhibition of cell growth. Among the compounds examined, 10% povidone‐iodine (PVP‐I) was the only antiseptic that exhibited more than 90% reduction of both biofilm formation and dispersion. In the group of sterilants and disinfectants, a formulation containing 7% hydrogen peroxide and 0.2% peracetic acid (HP‐PA), and sodium hypochlorite with 1% active chlorine (NaOCl) were equally effective.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.2011.00423.x