Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones

We disclose an organocatalyzed enantioselective decarboxylative ketone aldol reaction of β-ketoacids with trifluoromethyl ketones in the presence of biscinchona alkaloid (DHQD)(2)AQN, affording chiral tertiary alcohols in up to 98% yield and 90% ee.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-05, Vol.48 (36), p.4308-4310
Main Authors: Zheng, Yan, Xiong, Heng-Ying, Nie, Jing, Hua, Ming-Qing, Ma, Jun-An
Format: Article
Language:English
Subjects:
Biomimetics - methods
Catalysis
Keto Acids - chemistry
Ketones - chemistry
Stereoisomerism
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Summary:We disclose an organocatalyzed enantioselective decarboxylative ketone aldol reaction of β-ketoacids with trifluoromethyl ketones in the presence of biscinchona alkaloid (DHQD)(2)AQN, affording chiral tertiary alcohols in up to 98% yield and 90% ee.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc30949a