The Association of eNOS G894T Polymorphism with Metabolic Syndrome and Erectile Dysfunction

Accumulated evidences have outlined the potential relation between insulin resistance and endothelial dysfunction. The impaired ability of endothelium to synthesize or release nitric oxide may provide a common pathophysiological mechanism in the development of metabolic syndrome (MtS) and erectile d...

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Published in:Journal of sexual medicine 2012-03, Vol.9 (3), p.837-843
Main Authors: Lee, Yung‐Chin, Huang, Shu‐Pin, Liu, Chia‐Chu, Yang, Yi‐Hsin, Yeh, Hsin‐Chih, Li, Wei‐Ming, Wu, Wen‐Jeng, Wang, Chii‐Jye, Juan, Yung‐Shun, Huang, Chun‐Nung, Hour, Tzyh‐Chyuan, Chang, Chu‐Fen, Huang, Chun‐Hsiung
Format: Article
Language:English
Subjects:
Alleles
eNOS
Erectile Dysfunction
Erectile Dysfunction - epidemiology
Erectile Dysfunction - genetics
Genetic Predisposition to Disease
Heterozygote
Humans
Male
Metabolic Syndrome
Metabolic Syndrome - epidemiology
Metabolic Syndrome - genetics
Middle Aged
Nitric Oxide Synthase Type III - genetics
Polymorphism, Genetic
Prevalence
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Summary:Accumulated evidences have outlined the potential relation between insulin resistance and endothelial dysfunction. The impaired ability of endothelium to synthesize or release nitric oxide may provide a common pathophysiological mechanism in the development of metabolic syndrome (MtS) and erectile dysfunction (ED). The aim of this article was to investigate the genetic susceptibility of endothelial nitric oxide synthase (eNOS) G894T polymorphism underlying the development of both disorders. A total of 590 subjects with a mean (standard deviation) age of 55.3 years (4.1) were enrolled during a free health screening. Complete clinical data and questionnaires were taken for all subjects. Multivariate logistic regression analysis was used to determine the independent predictors of MtS and ED. The eNOS G894T polymorphism was determined using a polymerase chain reaction‐restriction fragment length polymorphism method. The definition of MtS was according to the modified criteria developed by the Bureau of Health Promotion in Taiwan. Patients with ED were defined as those having a five‐item International Index of Erectile Function (IIEF‐5)
ISSN:1743-6095
1743-6109
DOI:10.1111/j.1743-6109.2011.02588.x