High-Resolution Magnetic Resonance Myocardial Perfusion Imaging at 3.0-Tesla to Detect Hemodynamically Significant Coronary Stenoses as Determined by Fractional Flow Reserve

Objectives The objective of this study was to compare visual and quantitative analysis of high spatial resolution cardiac magnetic resonance (CMR) perfusion at 3.0-T against invasively determined fractional flow reserve (FFR). Background High spatial resolution CMR myocardial perfusion imaging for t...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2011-01, Vol.57 (1), p.70-75
Main Authors: Lockie, Timothy, BSc, MBChB, Ishida, Masaki, MD, PhD, Perera, Divaka, MD, Chiribiri, Amedeo, MD, De Silva, Kalpa, MBBS, Kozerke, Sebastian, PhD, Marber, Mike, MD, PhD, Nagel, Eike, MD, PhD, Rezavi, Reza, MD, Redwood, Simon, MD, Plein, Sven, MD, PhD
Format: Article
Language:English
Subjects:
Accuracy
Acute coronary syndromes
Angioplasty
Cardiology
Cardiovascular
Cardiovascular disease
Catheters
Confidence intervals
Coronary Circulation - physiology
coronary disease
Coronary Stenosis - diagnosis
Coronary Stenosis - physiopathology
Coronary vessels
Coronary Vessels - pathology
Coronary Vessels - physiopathology
Female
Follow-Up Studies
fractional flow reserve
Heart attacks
Humans
Image Enhancement
Internal Medicine
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Methods
Middle Aged
myocardial perfusion
Regional Blood Flow - physiology
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index
Studies
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Summary:Objectives The objective of this study was to compare visual and quantitative analysis of high spatial resolution cardiac magnetic resonance (CMR) perfusion at 3.0-T against invasively determined fractional flow reserve (FFR). Background High spatial resolution CMR myocardial perfusion imaging for the detection of coronary artery disease (CAD) has recently been proposed but requires further clinical validation. Methods Forty-two patients (33 men, age 57.4 ± 9.6 years) with known or suspected CAD underwent rest and adenosine-stress k -space and time sensitivity encoding accelerated perfusion CMR at 3.0-T achieving in-plane spatial resolution of 1.2 × 1.2 mm2 . The FFR was measured in all vessels with >50% severity stenosis. Fractional flow reserve
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2010.09.019