Fractalkine (CX3CL1) levels in patients with Behçet's disease and Neuro-Behçet's disease

Abstract Objective The aim of the present study was to assess the role of CX3CL1 in patients with active and inactive Behçet's Disease (BD), Neuro-Behçet's Disease (NBD) and control subjects. Methods Fifty-six patients admitted to the BD and NBD Outpatient Clinics, and 30 healthy controls...

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Bibliographic Details
Published in:Journal of the neurological sciences 2012-04, Vol.315 (1), p.120-122
Main Authors: Ceyla, Irkec, Tuba, Teksut Kuz, Esra, Adisen, Banu, Ozturk, Isil, Fidan, Ali, Gurer M, Turgut, Imir, Banu, Bozkurt
Format: Article
Language:English
Subjects:
Adult
Behcet Syndrome - blood
Behcet Syndrome - diagnosis
Behçet's disease
Biological and medical sciences
Biomarkers - blood
Chemokine CX3CL1 - blood
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Fractalkine (CX3CL1)
Humans
Male
Medical sciences
Middle Aged
Nervous System Diseases - blood
Nervous System Diseases - diagnosis
Neuro-Behçet's disease
Neurology
Young Adult
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Summary:Abstract Objective The aim of the present study was to assess the role of CX3CL1 in patients with active and inactive Behçet's Disease (BD), Neuro-Behçet's Disease (NBD) and control subjects. Methods Fifty-six patients admitted to the BD and NBD Outpatient Clinics, and 30 healthy controls were enrolled in the study. Serum CX3CL1 levels were measured by an enzyme linked immunosorbent assay (ELISA). Results No significant difference was found between the serum CX3CL1 levels of control subjects, and patients with active and inactive BD or NBD, regardless of treatment. Conclusion To our knowledge, this is the first study analyzing CX3CL1 levels in patients with BD and NBD. Our results demonstrated that serum CX3CL1 levels were not changed in active and inactive BD and NBD. However, further large-scale studies are needed to confirm our results.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2011.11.011