Changes in network dynamics during status epilepticus

Status epilepticus (SE) is an acute event, characterized by repeated or continuous seizures, which alters neuronal properties of the brain and can promote the epileptic disorder. Experimental observations indicate that SE becomes progressively less responsive to anti-epileptic drugs, suggesting chan...

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Bibliographic Details
Published in:Experimental neurology 2012-04, Vol.234 (2), p.454-465
Main Authors: Karunakaran, S., Grasse, D.W., Moxon, K.A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain
CA3 hippocampus
CA3 Region, Hippocampal - physiopathology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
In vivo
Kainic Acid
Medical sciences
Nerve Net - physiopathology
Nervous system (semeiology, syndromes)
Neurology
Neurons - physiology
Rats
Rats, Long-Evans
Status epilepticus
Status Epilepticus - chemically induced
Status Epilepticus - physiopathology
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Summary:Status epilepticus (SE) is an acute event, characterized by repeated or continuous seizures, which alters neuronal properties of the brain and can promote the epileptic disorder. Experimental observations indicate that SE becomes progressively less responsive to anti-epileptic drugs, suggesting changes in the underlying physiology. To assess the effect of SE on neuronal dynamics as it progresses, we measured changes in neuronal activity from CA3 hippocampus, ipsilateral and contralateral to a focal intrahippocampal injection of kainic acid during the full course of SE, 24h post-SE, and one week post-SE. The progressively intensifying behavioral response during SE was accompanied by changes in intrinsic firing properties of single neurons, LFP oscillations and interaction between single neurons and the oscillations. These results show important changes in neuronal and network activity underlying the progression of SE. ► Status epilepticus includes a distinct progression of neurophysiological changes. ► Population firing rate of pyramidal cells and interneurons decrease during SE. ► Cross correlations between pairs of neurons increases as SE progresses. ► Early in SE, cells increase coherence with the dominant oscillation in gamma band. ► Late in SE, cells decrease coherence with dominant oscillation in beta/alpha bands.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2012.01.020