Streptococcus pneumoniae pep27 mutant as a live vaccine for serotype-independent protection in mice

Highlights ► Pep27 is known to mediate lysis. ► Effect of the pep27 mutation on virulence was examined. ► The pep27 mutant showed rapid clearance and could not invade into the tissue. ► The pep27 mutant without adjuvant provides protective intranasal immunity.

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Bibliographic Details
Published in:Vaccine 2012-03, Vol.30 (11), p.2008-2019
Main Authors: Kim, Eun-Hye, Choi, Sang-Yoon, Kwon, Min-Kyoung, Tran, Thao Dang-Hien, Park, Sang-Sang, Lee, Kwang-Jun, Bae, Song-Mee, Briles, David E, Rhee, Dong-Kwon
Format: Article
Language:English
Subjects:
Administration, Intranasal
Allergy and Immunology
Animals
antibiotic resistance
Antibodies, Bacterial - blood
bacteremia
blood
brain
Cross-protection
Immunity
immunization
immunoglobulin G
Immunoglobulin G - blood
intravenous injection
Live vaccine
live vaccines
Male
Mice
morbidity
mortality
mutants
Mutation
pep27 mutant
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines - immunology
serotypes
Streptococcus pneumoniae
Streptococcus pneumoniae - genetics
Streptococcus pneumoniae - pathogenicity
Streptococcus pneumoniae - ultrastructure
Vaccines, Attenuated - immunology
Virulence
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Description
Summary:Highlights ► Pep27 is known to mediate lysis. ► Effect of the pep27 mutation on virulence was examined. ► The pep27 mutant showed rapid clearance and could not invade into the tissue. ► The pep27 mutant without adjuvant provides protective intranasal immunity.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.11.073