Amelioration of Age Associated Neuroinflammation on Long Term Bacosides Treatment

• Published in: Neurochemical research 2012-04, Vol.37 (4), p.869-874
• Main Authors: Rastogi, Manisha, Ojha, Rudra P., Devi, B. Parimala, Aggarwal, Aabha, Agrawal, Aruna, Dubey, G. P.
• Format: Article
• Language: English
• Subjects: Age; Aging; Aging - drug effects; Aging - metabolism; Aging - pathology; Animals; Bacopa; Bacopa monnieri; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brain; Cell Biology; Cognitive ability; Cortex; Cytokines; Female; Hippocampus; Inflammation; Inflammation - drug therapy; Inflammation - pathology; Inflammation - physiopathology; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - metabolism; Medicinal plants; Neurochemistry; Neurodegeneration; Neurology; Neuroprotection; Neuroprotective agents; Neuroprotective Agents - isolation & purification; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Neurosciences; Nitric-oxide synthase; Nitrite; Oral administration; Original Paper; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rats; Rats, Wistar; Saponins - isolation & purification; Saponins - pharmacology; Saponins - therapeutic use; Treatment Outcome
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1007/s11064-011-0681-1

Bacopa monnieri (L.) is a revered medicinal plant of traditional Indian system of medicine effective against cognitive impairment in ageing and SDAT. In our previous study, long term administration of bacosides was found to exhibit remarkable anti ageing effect, ameliorate age associated neurochemical and neurobehavioral deficits and prevent hippocampal neuronal degeneration in middle aged and aged rat brain cortex. In continuation to the previous study, the present study aims to investigate the neuroprotective effect of bacosides against age related chronic neuroinflammation in Wistar rat brain on 3 months treatment. Recently, neuroinflammation has gained considerable interest in age associated neurodegeneration and pathologies like SDAT due to its slow onset and chronic nature. The results of the present study demonstrated the significant attenuation of age dependant elevation of pro inflammatory cytokines, iNOS protein expression, total nitrite and lipofuscin content in middle aged and aged rat brain cortex on long term oral administration of bacosides. Thus, the present results suggest that bacosides possess immense potential to act as a neuroprotective agent due to its pleiotropic action for the prevention of ageing complications and SDAT progression.