Effect of N-Acetylcysteine and Fructose-1,6-Bisphosphate in the Treatment of Experimental Sepsis

Sepsis is a syndrome caused by uncontrolled systemic inflammatory response of the individual, which represents a serious epidemiological problem worldwide. The aim of this study was to investigate the effect of N-acetylcysteine (NAC) and fructose-1,6-bisphosphate (FBP) in the treatment of experiment...

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Published in:Inflammation 2011-12, Vol.34 (6), p.539-550
Main Authors: de Mello, Ricardo Obalski, Lunardelli, Adroaldo, Caberlon, Eduardo, de Moraes, Cristina Machado Bragança, Christ Vianna Santos, Roberto, da Costa, Vinicius Lorini, da Silva, Gabriela Viegas, da Silva Scherer, Patrícia, Buaes, Luiz Eduardo Coimbra, da Silva Melo, Denizar Alberto, Donadio, Márcio Vinícius Fagundes, Nunes, Fernanda Bordignon, de Oliveira, Jarbas Rodrigues
Format: Article
Language:English
Subjects:
Acetylcysteine - pharmacology
Acetylcysteine - therapeutic use
Animals
Biomedical and Life Sciences
Biomedicine
Drug Synergism
Drug Therapy, Combination
Escherichia coli
Fructose-Bisphosphatase - pharmacology
Fructose-Bisphosphatase - therapeutic use
Immunology
Internal Medicine
Pathology
Pharmacology/Toxicology
Rats
Rheumatology
Sepsis - drug therapy
Sepsis - mortality
Survival Rate
Treatment Outcome
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Summary:Sepsis is a syndrome caused by uncontrolled systemic inflammatory response of the individual, which represents a serious epidemiological problem worldwide. The aim of this study was to investigate the effect of N-acetylcysteine (NAC) and fructose-1,6-bisphosphate (FBP) in the treatment of experimental sepsis. We used rats that were divided into five experimental groups: normal control (not induced), septic control (induced using a capsule with non sterile fecal content and Escherichia coli ), treated with FBP (500 mg/kg i.p.), treated with NAC (150 mg/kg i.p.), and treated with the combination of FBP with NAC. In the group treated with NAC, 16.68% of the mice survived, the FBP reduced the mortality of mice during the acute stage of the disease and increased the animals’ survival time in 33.34%, and the combination of drugs had no effect. Our results show that NAC prevented the mortality of animals after septic induction. These data confirm the validity of the use of NAC in the treatment of sepsis. Our data also show that the synergistic action with FBP does not improve the picture.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-010-9261-9