Acute phase response in cattle infected with Anaplasma marginale

This study was undertaken to evaluate the acute phase responses via the assessment of the concentration of serum sialic acids (total, lipid bound and protein bound), inflammatory mediators (IFN-γ and TNF-α) and acute phase proteins (Hp and SAA) in 20 adult crossbred cattle naturally infected by Anap...

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Bibliographic Details
Published in:Veterinary microbiology 2012-03, Vol.155 (2-4), p.267-271
Main Authors: Nazifi, S., Razavi, S.M., Kaviani, F., Rakhshandehroo, E.
Format: Article
Language:English
Subjects:
Acute phase proteins
Acute-Phase Proteins - analysis
Acute-Phase Reaction - blood
Acute-Phase Reaction - immunology
Anaplasma marginale
Anaplasmosis - blood
Anaplasmosis - immunology
Animals
Bacteriology
Biological and medical sciences
Cattle
Cattle Diseases - blood
Cattle Diseases - immunology
Erythrocyte Count
erythrocytes
farms
ferroxidase
fibrinogen
Fundamental and applied biological sciences. Psychology
IFN-γ
Interferon-gamma - blood
lipids
Microbiology
Miscellaneous
Parasitemia - epidemiology
protein binding
Sialic acids
TNF-α
Tumor Necrosis Factor-alpha - blood
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Summary:This study was undertaken to evaluate the acute phase responses via the assessment of the concentration of serum sialic acids (total, lipid bound and protein bound), inflammatory mediators (IFN-γ and TNF-α) and acute phase proteins (Hp and SAA) in 20 adult crossbred cattle naturally infected by Anaplasma marginale. The infected animals were divided into 2 subgroups on the basis of parasitemia rate (20%). Also, as a control group, 10 clinically healthy cattle from the same farms were sampled. Our data revealed significant decreases in red blood cell count (RBC), hematocrite (PCV) and hemoglobine (Hb) in infected cattle compared to healthy ones. Conversely, the concentrations of Hp, SAA, ceruloplasmin, fibrinogen, serum sialic acids and the circulatory IFN-γ and TNF-α were increased in the diseased cattle (P
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2011.08.024