Bed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activation

Abstract Several studies from our group have indicated that the BNST play an important role in baroreflex modulation. However, the involvement of the BNST in the chemoreflex activity is unknown. Thus, in the present study, we investigated the effect of the local bed nucleus of stria terminalis (BNST...

Full description

Saved in:
Bibliographic Details
Published in:Autonomic neuroscience 2012-04, Vol.167 (1), p.21-26
Main Authors: Granjeiro, Érica M, Gomes, Felipe V, Alves, Fernando H.F, Crestani, Carlos C, Corrêa, Fernando M.A, Resstel, Leonardo B.M
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Autonomic nervous system
Autonomic Nervous System - physiology
Baroreceptors
Baroreflex - drug effects
bed nucleus
Blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
Cardiovascular system
Cardiovascular System - drug effects
Chemoreception (internal)
Cobalt - pharmacology
cobalt chloride
CoCl2
Heart rate
Heart Rate - drug effects
Heart Rate - physiology
Hemodynamics - physiology
Immunohistochemistry
Intravenous administration
KCN
Male
Medical Education
Microinjection
Nervous system
Neurotransmission
Potassium Chloride - pharmacology
Potassium Cyanide - pharmacology
Rats
Rats, Wistar
Reflex - physiology
Reflexes
Septal Nuclei - physiology
Stimulation, Chemical
Stria terminalis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Several studies from our group have indicated that the BNST play an important role in baroreflex modulation. However, the involvement of the BNST in the chemoreflex activity is unknown. Thus, in the present study, we investigated the effect of the local bed nucleus of stria terminalis (BNST) neurotransmission inhibition by bilateral microinjections of the non-selective synaptic blocker cobalt chloride (CoCl2 ) on the cardiovascular responses to chemoreflex activation in rats. For this purpose, chemoreflex was activated with KCN (i.v.) before and after microinjections of CoCl2 into the BNST. Reversible BNST inactivation produced no significant changes in the magnitude and durations of both pressor and bradycardic responses to intravenous KCN infusion. These findings suggesting that BNST neurotransmission have not influence on both sympathoexcitatory and parasympathoexcitatory components of the peripheral chemoreflex activation.
ISSN:1566-0702
1872-7484
DOI:10.1016/j.autneu.2011.11.004