Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus

Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of motor neuron and various cognitive deficits including writing errors.11 C-flumazenil (FMZ), the positron emission tomography (PET) GABAA receptor ligand, is a marker of cortical dysfunction. The obj...

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Bibliographic Details
Published in:Journal of the neurological sciences 2012-04, Vol.315 (1), p.55-59
Main Authors: Yabe, Ichiro, Tsuji-Akimoto, Sachiko, Shiga, Tohru, Hamada, Shinsuke, Hirata, Kenji, Otsuki, Mika, Kuge, Yuji, Tamaki, Nagara, Sasaki, Hidenao
Format: Article
Language:English
Subjects:
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - complications
Amyotrophic Lateral Sclerosis - pathology
Amyotrophic Lateral Sclerosis - psychology
Anterior cingulate gyrus
Biological and medical sciences
Brain Mapping - methods
Cognition Disorders - complications
Cognition Disorders - pathology
Cognition Disorders - psychology
Cognitive dysfunction
Female
Gyrus Cinguli - pathology
Humans
Male
Medical sciences
Middle Aged
Neurology
Neurons - pathology
Neuropsychological Tests
Orthopedic surgery
PET
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Writing
Writing error
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Summary:Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of motor neuron and various cognitive deficits including writing errors.11 C-flumazenil (FMZ), the positron emission tomography (PET) GABAA receptor ligand, is a marker of cortical dysfunction. The objective of this study was to investigate the relationship between cognitive deficits and loss of neuronal integrity in ALS patients using11 C-FMZ PET. Ten patients with ALS underwent both neuropsychological tests and11 C-FMZ-PET. The binding potential (BP) of FMZ was calculated from11 C-FMZ PET images. There were no significant correlations between the BP and most test scores except for the writing error index (WEI), which was measured by the modified Western Aphasia Battery — VB (WAB-IVB) test. The severity of writing error was associated with loss of neuronal integrity in the bilateral anterior cingulate gyrus with mild right predominance (n = 9; x = 4 mm, y = 36 mm, z = 4 mm, Z = 5.1). The results showed that writing errors in our patients with ALS were related to dysfunction in the anterior cingulate gyrus.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2011.11.039