A single centre’s experience of stereotactic radiosurgery and radiotherapy for non-functioning pituitary adenomas with the Linear Accelerator (Linac)

Abstract Non-functioning pituitary adenomas are primarily a surgically managed pathology, but recurrence or regrowth is not uncommon. Previous large series have retrospectively validated the use of the Gamma Knife (GK) as an adjuvant treatment. To our knowledge, we present the largest case series to...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2012-03, Vol.19 (3), p.370-374
Main Authors: Wilson, P.J, De-loyde, K.J, Williams, J.R, Smee, R.I
Format: Article
Language:English
Subjects:
Adenoma - pathology
Adenoma - radiotherapy
Adenoma - surgery
Adolescent
Adult
Aged
Aged, 80 and over
Child
Disease-Free Survival
Endpoint Determination
Female
Hormone Replacement Therapy
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neurology
Particle Accelerators
Pituitary gland
Pituitary Neoplasms - pathology
Pituitary Neoplasms - radiotherapy
Pituitary Neoplasms - surgery
Progression-free survival
Radiological progression
Radiosurgery - adverse effects
Radiosurgery - methods
Radiotherapy
Stereotactic radiotherapy
Survival Analysis
Treatment Outcome
Young Adult
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Summary:Abstract Non-functioning pituitary adenomas are primarily a surgically managed pathology, but recurrence or regrowth is not uncommon. Previous large series have retrospectively validated the use of the Gamma Knife (GK) as an adjuvant treatment. To our knowledge, we present the largest case series to date with the Linear Accelerator (Linac) for the management of this pathology. In this study we review the clinical course of 118 patients, 51 of whom had stereotactic radiosurgery (SRS) and 67 who had fractionated stereotactic radiotherapy (FSRT); the discriminatory feature being proximity to the optic chiasm. For comparison purposes a population of 53 patients who had conventional radiotherapy (CRT) is included. The local control rates at 5 years for SRS, FRST and CRT were 100%, 93% and 87% respectively. Treatment-related morbidity was low. These data confirm that Linac SRS and FSRT are safe and effective for the treatment of non-functioning pituitary adenomas.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2011.07.025