Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus

KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K...

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Bibliographic Details
Published in:Molecular genetics and metabolism 2012-03, Vol.105 (3), p.525-527
Main Authors: Tavira, Beatriz, Coto, Eliecer, Torres, Armando, Díaz-Corte, Carmen, Díaz-Molina, Beatriz, Ortega, Francisco, Arias, Manuel, Díaz, Juan M., Selgas, Rafael, López-Larrea, Carlos, Ruiz-Ortega, Marta, Ortiz, Alberto, González, Elena, Campistol, Josep M., Alvarez, Victoria
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Calcineurin Inhibitors
Diabetes Mellitus, Type 2 - chemically induced
Diabetes Mellitus, Type 2 - genetics
Female
Genetic association
Genotype
Heart Transplantation - adverse effects
Humans
Immunosuppressive Agents - adverse effects
Insulin - metabolism
Insulin Secretion
Insulin-Secreting Cells - drug effects
KCNJ11
Kidney Transplantation - adverse effects
Male
Middle Aged
Polymorphism, Single Nucleotide
Postransplant diabetes
Potassium Channels, Inwardly Rectifying - genetics
Tacrolimus - adverse effects
Tacrolimus - therapeutic use
Young Adult
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Summary:KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association. ► A KCNJ11 SNP was associated with diabetes in tacrolimus treated transplanted patients. ► KCNJ11 sequencing showed that this SNP was directly responsible for the association. ► The effect of KCNJ11 on beta cells insulin release could explain this association.
ISSN:1096-7192
1096-7206
DOI:10.1016/j.ymgme.2011.12.020