Loading…
Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus
KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K...
Saved in:
| Published in: | Molecular genetics and metabolism 2012-03, Vol.105 (3), p.525-527 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c436t-55a911b23cd4042c44641fa78697107d7cb0353850880f8379ade098e30049213 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c436t-55a911b23cd4042c44641fa78697107d7cb0353850880f8379ade098e30049213 |
| container_end_page | 527 |
| container_issue | 3 |
| container_start_page | 525 |
| container_title | Molecular genetics and metabolism |
| container_volume | 105 |
| creator | Tavira, Beatriz Coto, Eliecer Torres, Armando Díaz-Corte, Carmen Díaz-Molina, Beatriz Ortega, Francisco Arias, Manuel Díaz, Juan M. Selgas, Rafael López-Larrea, Carlos Ruiz-Ortega, Marta Ortiz, Alberto González, Elena Campistol, Josep M. Alvarez, Victoria |
| description | KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association.
► A KCNJ11 SNP was associated with diabetes in tacrolimus treated transplanted patients. ► KCNJ11 sequencing showed that this SNP was directly responsible for the association. ► The effect of KCNJ11 on beta cells insulin release could explain this association. |
| doi_str_mv | 10.1016/j.ymgme.2011.12.020 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_968178778</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1096719211006627</els_id><sourcerecordid>968178778</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-55a911b23cd4042c44641fa78697107d7cb0353850880f8379ade098e30049213</originalsourceid><addsrcrecordid>eNp9kT1vFDEQhlcIRD7gFyAhd4RiF4_3w3ZBEZ0gfETQhNryeeeIT-v14vFxupo_jsMllKlsWc-8M56nql4Bb4DD8G7bHMLPgI3gAA2Ihgv-pDoFrodaCj48fbiDFifVGdGWF7DX3fPqRAgxdFLx0-rPJVF03mYfZ7bGvEecmWUuhlAevq6-fQFgS5wOIabl1lNgF4l6Afots_PIZtzXcSbMhaGck51pmeyc2ehtSUNifmZLScc5E8sJbcaR7X2-ZTfWpTj5sKMX1bONnQhf3p_n1Y-PH25Wn-rr71efV5fXtevaIdd9bzXAWrRu7HgnXNcNHWysVIOWwOUo3Zq3fat6rhTfqFZqOyLXClvOOy2gPa_eHHOXFH_tkLIJnhxOZWCMOzJ6UCCVlKqQF4-SwLmQuhVKFrQ9ouU3RAk3Zkk-2HQokLnzZLbmnydz58mAMMVTqXp932C3Djj-r3kQU4D3RwDLQn57TIZcWaLD0Sd02YzRP9rgL-4QpC0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1002793287</pqid></control><display><type>article</type><title>Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus</title><source>Elsevier</source><creator>Tavira, Beatriz ; Coto, Eliecer ; Torres, Armando ; Díaz-Corte, Carmen ; Díaz-Molina, Beatriz ; Ortega, Francisco ; Arias, Manuel ; Díaz, Juan M. ; Selgas, Rafael ; López-Larrea, Carlos ; Ruiz-Ortega, Marta ; Ortiz, Alberto ; González, Elena ; Campistol, Josep M. ; Alvarez, Victoria</creator><creatorcontrib>Tavira, Beatriz ; Coto, Eliecer ; Torres, Armando ; Díaz-Corte, Carmen ; Díaz-Molina, Beatriz ; Ortega, Francisco ; Arias, Manuel ; Díaz, Juan M. ; Selgas, Rafael ; López-Larrea, Carlos ; Ruiz-Ortega, Marta ; Ortiz, Alberto ; González, Elena ; Campistol, Josep M. ; Alvarez, Victoria ; The Pharmacogenetics of tacrolimus REDINREN study group ; Pharmacogenetics of tacrolimus REDINREN study group</creatorcontrib><description>KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association.
► A KCNJ11 SNP was associated with diabetes in tacrolimus treated transplanted patients. ► KCNJ11 sequencing showed that this SNP was directly responsible for the association. ► The effect of KCNJ11 on beta cells insulin release could explain this association.</description><identifier>ISSN: 1096-7192</identifier><identifier>EISSN: 1096-7206</identifier><identifier>DOI: 10.1016/j.ymgme.2011.12.020</identifier><identifier>PMID: 22264780</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Calcineurin Inhibitors ; Diabetes Mellitus, Type 2 - chemically induced ; Diabetes Mellitus, Type 2 - genetics ; Female ; Genetic association ; Genotype ; Heart Transplantation - adverse effects ; Humans ; Immunosuppressive Agents - adverse effects ; Insulin - metabolism ; Insulin Secretion ; Insulin-Secreting Cells - drug effects ; KCNJ11 ; Kidney Transplantation - adverse effects ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Postransplant diabetes ; Potassium Channels, Inwardly Rectifying - genetics ; Tacrolimus - adverse effects ; Tacrolimus - therapeutic use ; Young Adult</subject><ispartof>Molecular genetics and metabolism, 2012-03, Vol.105 (3), p.525-527</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-55a911b23cd4042c44641fa78697107d7cb0353850880f8379ade098e30049213</citedby><cites>FETCH-LOGICAL-c436t-55a911b23cd4042c44641fa78697107d7cb0353850880f8379ade098e30049213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22264780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tavira, Beatriz</creatorcontrib><creatorcontrib>Coto, Eliecer</creatorcontrib><creatorcontrib>Torres, Armando</creatorcontrib><creatorcontrib>Díaz-Corte, Carmen</creatorcontrib><creatorcontrib>Díaz-Molina, Beatriz</creatorcontrib><creatorcontrib>Ortega, Francisco</creatorcontrib><creatorcontrib>Arias, Manuel</creatorcontrib><creatorcontrib>Díaz, Juan M.</creatorcontrib><creatorcontrib>Selgas, Rafael</creatorcontrib><creatorcontrib>López-Larrea, Carlos</creatorcontrib><creatorcontrib>Ruiz-Ortega, Marta</creatorcontrib><creatorcontrib>Ortiz, Alberto</creatorcontrib><creatorcontrib>González, Elena</creatorcontrib><creatorcontrib>Campistol, Josep M.</creatorcontrib><creatorcontrib>Alvarez, Victoria</creatorcontrib><creatorcontrib>The Pharmacogenetics of tacrolimus REDINREN study group</creatorcontrib><creatorcontrib>Pharmacogenetics of tacrolimus REDINREN study group</creatorcontrib><title>Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus</title><title>Molecular genetics and metabolism</title><addtitle>Mol Genet Metab</addtitle><description>KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association.
► A KCNJ11 SNP was associated with diabetes in tacrolimus treated transplanted patients. ► KCNJ11 sequencing showed that this SNP was directly responsible for the association. ► The effect of KCNJ11 on beta cells insulin release could explain this association.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Calcineurin Inhibitors</subject><subject>Diabetes Mellitus, Type 2 - chemically induced</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Female</subject><subject>Genetic association</subject><subject>Genotype</subject><subject>Heart Transplantation - adverse effects</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Insulin-Secreting Cells - drug effects</subject><subject>KCNJ11</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Postransplant diabetes</subject><subject>Potassium Channels, Inwardly Rectifying - genetics</subject><subject>Tacrolimus - adverse effects</subject><subject>Tacrolimus - therapeutic use</subject><subject>Young Adult</subject><issn>1096-7192</issn><issn>1096-7206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kT1vFDEQhlcIRD7gFyAhd4RiF4_3w3ZBEZ0gfETQhNryeeeIT-v14vFxupo_jsMllKlsWc-8M56nql4Bb4DD8G7bHMLPgI3gAA2Ihgv-pDoFrodaCj48fbiDFifVGdGWF7DX3fPqRAgxdFLx0-rPJVF03mYfZ7bGvEecmWUuhlAevq6-fQFgS5wOIabl1lNgF4l6Afots_PIZtzXcSbMhaGck51pmeyc2ehtSUNifmZLScc5E8sJbcaR7X2-ZTfWpTj5sKMX1bONnQhf3p_n1Y-PH25Wn-rr71efV5fXtevaIdd9bzXAWrRu7HgnXNcNHWysVIOWwOUo3Zq3fat6rhTfqFZqOyLXClvOOy2gPa_eHHOXFH_tkLIJnhxOZWCMOzJ6UCCVlKqQF4-SwLmQuhVKFrQ9ouU3RAk3Zkk-2HQokLnzZLbmnydz58mAMMVTqXp932C3Djj-r3kQU4D3RwDLQn57TIZcWaLD0Sd02YzRP9rgL-4QpC0</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Tavira, Beatriz</creator><creator>Coto, Eliecer</creator><creator>Torres, Armando</creator><creator>Díaz-Corte, Carmen</creator><creator>Díaz-Molina, Beatriz</creator><creator>Ortega, Francisco</creator><creator>Arias, Manuel</creator><creator>Díaz, Juan M.</creator><creator>Selgas, Rafael</creator><creator>López-Larrea, Carlos</creator><creator>Ruiz-Ortega, Marta</creator><creator>Ortiz, Alberto</creator><creator>González, Elena</creator><creator>Campistol, Josep M.</creator><creator>Alvarez, Victoria</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201203</creationdate><title>Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus</title><author>Tavira, Beatriz ; Coto, Eliecer ; Torres, Armando ; Díaz-Corte, Carmen ; Díaz-Molina, Beatriz ; Ortega, Francisco ; Arias, Manuel ; Díaz, Juan M. ; Selgas, Rafael ; López-Larrea, Carlos ; Ruiz-Ortega, Marta ; Ortiz, Alberto ; González, Elena ; Campistol, Josep M. ; Alvarez, Victoria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-55a911b23cd4042c44641fa78697107d7cb0353850880f8379ade098e30049213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Calcineurin Inhibitors</topic><topic>Diabetes Mellitus, Type 2 - chemically induced</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Female</topic><topic>Genetic association</topic><topic>Genotype</topic><topic>Heart Transplantation - adverse effects</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Insulin-Secreting Cells - drug effects</topic><topic>KCNJ11</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Postransplant diabetes</topic><topic>Potassium Channels, Inwardly Rectifying - genetics</topic><topic>Tacrolimus - adverse effects</topic><topic>Tacrolimus - therapeutic use</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tavira, Beatriz</creatorcontrib><creatorcontrib>Coto, Eliecer</creatorcontrib><creatorcontrib>Torres, Armando</creatorcontrib><creatorcontrib>Díaz-Corte, Carmen</creatorcontrib><creatorcontrib>Díaz-Molina, Beatriz</creatorcontrib><creatorcontrib>Ortega, Francisco</creatorcontrib><creatorcontrib>Arias, Manuel</creatorcontrib><creatorcontrib>Díaz, Juan M.</creatorcontrib><creatorcontrib>Selgas, Rafael</creatorcontrib><creatorcontrib>López-Larrea, Carlos</creatorcontrib><creatorcontrib>Ruiz-Ortega, Marta</creatorcontrib><creatorcontrib>Ortiz, Alberto</creatorcontrib><creatorcontrib>González, Elena</creatorcontrib><creatorcontrib>Campistol, Josep M.</creatorcontrib><creatorcontrib>Alvarez, Victoria</creatorcontrib><creatorcontrib>The Pharmacogenetics of tacrolimus REDINREN study group</creatorcontrib><creatorcontrib>Pharmacogenetics of tacrolimus REDINREN study group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Molecular genetics and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tavira, Beatriz</au><au>Coto, Eliecer</au><au>Torres, Armando</au><au>Díaz-Corte, Carmen</au><au>Díaz-Molina, Beatriz</au><au>Ortega, Francisco</au><au>Arias, Manuel</au><au>Díaz, Juan M.</au><au>Selgas, Rafael</au><au>López-Larrea, Carlos</au><au>Ruiz-Ortega, Marta</au><au>Ortiz, Alberto</au><au>González, Elena</au><au>Campistol, Josep M.</au><au>Alvarez, Victoria</au><aucorp>The Pharmacogenetics of tacrolimus REDINREN study group</aucorp><aucorp>Pharmacogenetics of tacrolimus REDINREN study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus</atitle><jtitle>Molecular genetics and metabolism</jtitle><addtitle>Mol Genet Metab</addtitle><date>2012-03</date><risdate>2012</risdate><volume>105</volume><issue>3</issue><spage>525</spage><epage>527</epage><pages>525-527</pages><issn>1096-7192</issn><eissn>1096-7206</eissn><abstract>KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association.
► A KCNJ11 SNP was associated with diabetes in tacrolimus treated transplanted patients. ► KCNJ11 sequencing showed that this SNP was directly responsible for the association. ► The effect of KCNJ11 on beta cells insulin release could explain this association.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22264780</pmid><doi>10.1016/j.ymgme.2011.12.020</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1096-7192 |
| ispartof | Molecular genetics and metabolism, 2012-03, Vol.105 (3), p.525-527 |
| issn | 1096-7192 1096-7206 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_968178778 |
| source | Elsevier |
| subjects | Adolescent Adult Aged Calcineurin Inhibitors Diabetes Mellitus, Type 2 - chemically induced Diabetes Mellitus, Type 2 - genetics Female Genetic association Genotype Heart Transplantation - adverse effects Humans Immunosuppressive Agents - adverse effects Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects KCNJ11 Kidney Transplantation - adverse effects Male Middle Aged Polymorphism, Single Nucleotide Postransplant diabetes Potassium Channels, Inwardly Rectifying - genetics Tacrolimus - adverse effects Tacrolimus - therapeutic use Young Adult |
| title | Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T04%3A11%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20a%20common%20KCNJ11%20polymorphism%20(rs5219)%20and%20new-onset%20posttransplant%20diabetes%20in%20patients%20treated%20with%20Tacrolimus&rft.jtitle=Molecular%20genetics%20and%20metabolism&rft.au=Tavira,%20Beatriz&rft.aucorp=The%20Pharmacogenetics%20of%20tacrolimus%20REDINREN%20study%20group&rft.date=2012-03&rft.volume=105&rft.issue=3&rft.spage=525&rft.epage=527&rft.pages=525-527&rft.issn=1096-7192&rft.eissn=1096-7206&rft_id=info:doi/10.1016/j.ymgme.2011.12.020&rft_dat=%3Cproquest_cross%3E968178778%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c436t-55a911b23cd4042c44641fa78697107d7cb0353850880f8379ade098e30049213%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1002793287&rft_id=info:pmid/22264780&rfr_iscdi=true |