Highly Enantioselective Synthesis of 2,3-Dihydroquinazolinones through Intramolecular Amidation of Imines

Enantioselective synthesis of 2,3-dihydroquinazolinones (DHQZs) was accomplished using readily available Sc(III)-inda-pybox as the catalyst. This is the first report on the metal catalyzed asymmetric intramolecular amidation of imines to synthesize DHQZs.

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Bibliographic Details
Published in:Organic letters 2012-04, Vol.14 (7), p.1896-1899
Main Authors: Prakash, Muthuraj, Kesavan, Venkitasamy
Format: Article
Language:English
Subjects:
Catalysis
Imines - chemistry
Molecular Structure
Quinazolinones - chemical synthesis
Quinazolinones - chemistry
Stereoisomerism
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Summary:Enantioselective synthesis of 2,3-dihydroquinazolinones (DHQZs) was accomplished using readily available Sc(III)-inda-pybox as the catalyst. This is the first report on the metal catalyzed asymmetric intramolecular amidation of imines to synthesize DHQZs.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol300518m