Age Difference in Morphology and Immunohistology inthe Thymus and Spleen in Crl:CD (SD) Rats

We investigated chronological changes in immunohistochemical phenotyping in the thymus and spleen in Crl:CD rats up to the age of about one year. In the thymus, T cells increased markedly from 3 to 4 weeks of age. Proliferating cells also increased markedly at these points. B cells tended towards an...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2012, Vol.25(1), pp.55-61
Main Authors: Kodama, Rinya, Okazaki, Takanobu, Sato, Tamio, Iwashige, Shuichiro, Tanigawa, Yohei, Fujishima, Junko, Moriyama, Akiko, Yamashita, Nobuyoshi, Sasaki, Yuji, Yoshikawa, Tsuyoshi, Kamimura, Yasuhiro, Maeda, Hiroshi
Format: Article
Language:English
Subjects:
Age
Age differences
development
Follicles
immunohistochemistry
Lymph
Lymphocytes B
Lymphocytes T
periarteriolar lymphoid sheath
Phenotyping
pleen
SD rat
Spleen
Thymus
weaning
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Summary:We investigated chronological changes in immunohistochemical phenotyping in the thymus and spleen in Crl:CD rats up to the age of about one year. In the thymus, T cells increased markedly from 3 to 4 weeks of age. Proliferating cells also increased markedly at these points. B cells tended towards an increase with age. In the spleen, white pulp increased until 9 weeks of age and remained fairly stable thereafter. In the periarteriolar lymphoid sheath and marginal zone, T cells gradually increased until 9 weeks of age and became almost flat thereafter. In the lymph follicle, T cells increased with age. B cells tended towards an increase with age in all areas of the spleen. It was concluded that development of the thymus was most marked from 3 to 4 weeks of age and that both the thymus and spleen had matured by 9 weeks of age.
ISSN:0914-9198
1881-915X
DOI:10.1293/tox.25.55