Is C677T Polymorphism in Methylenetetrahydrofolate Reductase Gene a Risk Factor for Diabetic Nephropathy or Diabetes Mellitus in a Chinese Population?

• Published in: Archives of medical research 2012, Vol.43 (1), p.42-50
• Main Authors: Cui, Wen-peng, Du, Bing, Jia, Ye, Zhou, Wen-hua, Liu, Sheng-mao, Cui, Ying-chun, Ma, Fu-zhe, Luo, Ping, Miao, Li-ning
• Format: Article
• Language: English
• Subjects: Asian Continental Ancestry Group; C677T Polymorphism; Case-Control Studies; Diabetes mellitus; Diabetes Mellitus - enzymology; Diabetes Mellitus - genetics; Diabetic Nephropathies - enzymology; Diabetic Nephropathies - genetics; Diabetic nephropathy; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Internal Medicine; Meta-analysis; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Polymorphism, Single Nucleotide; Publication Bias; Risk Factors
• ISSN: 0188-4409; 1873-5487
• DOI: 10.1016/j.arcmed.2011.12.003

Background and Aims To date, case-control studies on the association between C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene and diabetes mellitus (DM) or diabetic nephropathy (DN) in different populations have provided inconclusive results. To clarify the effect of the C677T polymorphism on the risk of both DM and DN in a Chinese population, a meta-analysis was performed. Methods A comprehensive literature search was conducted to collect data from all case-control observational studies that investigated association of C677T polymorphism in MTHFR gene with DM or DN in a Chinese population. Results Overall, 12 studies in a Chinese population published up to 2011 were combined, and the heterogeneity among them varied from none to moderate. The 677T allele showed significant association with DN (OR = 1.97, 95% CI [1.71, 2.28], p