Albendazole and Colchicine Modulate LPS-Induced Secretion of Inflammatory Mediators by Liver Macrophages

Colchicine and albendazole inhibited LPS-induced secretion of TNF-α and NO in a primary culture of rat Kupffer cells. Both agents potentiated the stimulating effect of this toxin on prostaglandin E 2 secretion. The amount of prostaglandin D 2 remained unchanged under these conditions.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011-10, Vol.151 (6), p.683-685
Main Authors: Viktorov, A. V., Yurkiv, V. A.
Format: Article
Language:English
Subjects:
Albendazole
Albendazole - pharmacology
Animals
Biomedical and Life Sciences
Biomedicine
Carbamates
Cell Biology
Cells, Cultured
Colchicine
Colchicine - pharmacology
Inflammation Mediators - metabolism
Internal Medicine
Laboratory Medicine
Lipopolysaccharides - pharmacology
Liver
Liver - drug effects
Liver - metabolism
Macrophages
Macrophages - drug effects
Macrophages - metabolism
Male
Mitogens
Pathology
Pharmacology and Toxicology
Rats
Rats, Sprague-Dawley
Tubulins
Tumor Necrosis Factor-alpha - metabolism
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Description
Summary:Colchicine and albendazole inhibited LPS-induced secretion of TNF-α and NO in a primary culture of rat Kupffer cells. Both agents potentiated the stimulating effect of this toxin on prostaglandin E 2 secretion. The amount of prostaglandin D 2 remained unchanged under these conditions.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1415-8