Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice

Highlights ► We evaluated the immunogenicity of VZV glycoprotein E-based herpes zoster vaccines. ► Mice were immunized with gE combined with saline, Al salt or an Adjuvant System. ► Adjuvant Systems AS01 and AS02 contain the immunostimulants QS21 and MPL. ► gE formulated with an Adjuvant System elic...

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Bibliographic Details
Published in:Vaccine 2012-04, Vol.30 (20), p.3126-3135
Main Authors: Dendouga, Najoua, Fochesato, Michel, Lockman, Laurence, Mossman, Sally, Giannini, Sandra L
Format: Article
Language:English
Subjects:
Adjuvant System
Adjuvants
Adjuvants, Immunologic - administration & dosage
Age
Allergy and Immunology
Alum Compounds - administration & dosage
Aluminum
Animal models
Animals
Antibodies
CD4 antigen
CD4-Positive T-Lymphocytes - immunology
Confidence intervals
gamma -Interferon
Glycoprotein E
Herpes zoster
Herpes zoster vaccine
Herpes Zoster Vaccine - administration & dosage
Herpes Zoster Vaccine - immunology
Immune response (cell-mediated)
Immunity (cell-mediated)
Immunization
Immunogenicity
Immunology
Immunostimulants
Infections
Interferon-gamma - secretion
Interleukin 2
Interleukin-2 - secretion
Laboratory animals
Lipid A
Lymphocytes
Lymphocytes T
Mice
Neuralgia
Pathogenesis
Proteins
Risk factors
Salts
Saponins - administration & dosage
Toll-Like Receptors - agonists
Vaccines
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - immunology
Varicella-zoster virus
Viral Envelope Proteins - immunology
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Description
Summary:Highlights ► We evaluated the immunogenicity of VZV glycoprotein E-based herpes zoster vaccines. ► Mice were immunized with gE combined with saline, Al salt or an Adjuvant System. ► Adjuvant Systems AS01 and AS02 contain the immunostimulants QS21 and MPL. ► gE formulated with an Adjuvant System elicited higher CD4+ T cell responses than other vaccines. ► gE formulated with AS01B induced higher CMI responses compared to other gE/AS01 formulations, supporting clinical evaluation.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.01.088