Effect of Blood Donation Mediated Volume Reduction on Right Ventricular Function Parameters in Healthy Subjects

• Published in: Echocardiography (Mount Kisco, N.Y.) N.Y.), 2012-04, Vol.29 (4), p.451-454
• Main Authors: Kucukdurmaz, Zekeriya, Karapinar, Hekim, Karavelioğlu, Yusuf, Açar, Göksel, Gul, Ibrahim, Emiroglu, Mehmet Yunus, Bulut, Mustafa, Esen, Ali Metin
• Format: Article
• Language: English
• Subjects: Adult; Blood Donors; Echocardiography - methods; Elasticity Imaging Techniques - methods; Female; Heart Ventricles - diagnostic imaging; Humans; myocardial performance index; Organ Size; Reproducibility of Results; right heart; Sensitivity and Specificity; systolic function; tissue Doppler; tricuspid annular plane systolic excursion; Ventricular Function, Right - physiology
• ISSN: 0742-2822; 1540-8175
• DOI: 10.1111/j.1540-8175.2011.01614.x

Purpose: We aimed to investigate the effect of controlled and limited volume change by the blood donation model to the right ventricular (RV) function via different echocardiographic parameters in healthy adults. Methods: Study population was composed of 71 healthy subjects who were volunteers for blood donation and evaluated before and after 450 mL blood donation. Pulsed‐wave Doppler of the RV inflow and tissue Doppler of tricuspid lateral annulus, and tricuspid annular plane systolic excursion (TAPSE) were assessed. Results: E velocity of inflow decreased significantly (67.6 ± 15.9 vs 60.9 ± 12.2, P = 0.006). S’ and A’ velocities did not change (15.3 ± 3.2 vs 15.2 ± 2.5 cm/s, P = NS; 14.1 ± 3.3 vs 13.4 ± 3.1 cm/s, P = NS, respectively) but E’ showed significant decrease (13.7 ± 2.9 vs 12.2 ± 3.2 cm/s, P = 0.011). E’/A’ ratio and E/E’ ratio were found to be unchanged (1.0 ± 0.3 vs 1.0 ± 0.4, P = NS; 5.1 ± 2 vs 5.3 ± 2, P = NS, respectively). Myocardial performance index (MPI) was found to be increased but ejection time obtained from the tricuspid annulus did not change (0.50 ± 0.13 vs 0.54 ± 0.11, P = 0.040; 243 ± 37 vs 240 ± 27, P = NS, respectively). Isovolumetric relaxation and contraction times showed difference close to the significance limit (56 ± 19 vs 64 ± 23 ms, P = 0.055; 61 ± 16 vs 67 ± 16 ms, P = 0.062, respectively). TAPSE decreased significantly (2.62 ± 0.29 vs 2.41 ± 0.27 mm, P = 0.005). Conclusion: E’ velocity and TAPSE were sensitive to a volume reduction as little as 450 mL in healthy subjects. MPI index of the tricuspid annulus is less sensitive than E’ and TAPSE but need much care under changing volume state. However S’ and A’ velocity and E’/A’ ratio were found to be resistant to the effects of volume depletion. (Echocardiography 2012;29:451‐454)