The structure of glibenclamide in the solid state

The structure of glibenclamide, 5‐chloro‐N‐(2‐{4‐[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)‐2‐methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility th...

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Published in:Magnetic resonance in chemistry 2012-03, Vol.50 (3), p.246-255
Main Authors: Sanz, Dionisia, Claramunt, Rosa M., Alkorta, Ibon, Sánchez-Sanz, Goar, Elguero, José
Format: Article
Language:English
Subjects:
B3LYP/6-311++G(d
B3LYP/6‐311++G(d,p)
Crystallography, X-Ray
GIAO
Glyburide - chemistry
Magnetic Resonance Spectroscopy - standards
Models, Molecular
Molecular Structure
Quantum Theory
Reference Standards
SSNMR
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Summary:The structure of glibenclamide, 5‐chloro‐N‐(2‐{4‐[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)‐2‐methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility that glibenclamide suffers a tautomerization under melting to afford a desmotrope was rejected. Copyright © 2012 John Wiley & Sons, Ltd. The structure of glibenclamide, 5‐chloro‐N‐(2‐{4‐[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)‐2‐methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility that glibenclamide suffers a tautomerization under melting to afford a desmotrope was rejected.
ISSN:0749-1581
1097-458X
DOI:10.1002/mrc.2868