Loading…
The expression of ferritin, lactoferrin, transferrin receptor and solute carrier family 11A1 in the host response to BCG-vaccination and Mycobacterium tuberculosis challenge
Highlights ► Splenocytes from BCG and naïve guinea pigs were used to study ferritin levels. ► Ferritin was suppressed in vaccine-derived cells after PPD stimulation. ► TNFα and NO were involved in ferritin suppression. ► Microarray revealed suppression of further iron-related genes after M. tubercul...
Saved in:
Published in: | Vaccine 2012-05, Vol.30 (21), p.3159-3168 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Highlights ► Splenocytes from BCG and naïve guinea pigs were used to study ferritin levels. ► Ferritin was suppressed in vaccine-derived cells after PPD stimulation. ► TNFα and NO were involved in ferritin suppression. ► Microarray revealed suppression of further iron-related genes after M. tuberculosis infection. ► The regulation of iron is an important mechanism induced by BCG-vaccination. |
---|---|
ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/j.vaccine.2012.03.008 |