Sodium Alginate Oligosaccharides Attenuate Hypertension and Associated Kidney Damage in Dahl Salt-Sensitive Rats Fed a High-Salt Diet

• Published in: Clinical and experimental hypertension (1993) 2012-04, Vol.34 (2), p.99-106
• Main Authors: Terakado, Shouko, Ueno, Mai, Tamura, Yuki, Toda, Natsuko, Yoshinaga, Mariko, Otsuka, Kie, Numabe, Atsushi, Kawabata, Yukari, Murota, Itsuki, Sato, Nobuyuki, Uehara, Yoshio
• Format: Article
• Language: English
• Subjects: alginate; Alginates - chemistry; Alginates - pharmacology; Animals; Antihypertensive Agents - pharmacology; Blood Pressure - drug effects; Creatinine - metabolism; Dahl rats; Glucuronic Acid - chemistry; Glucuronic Acid - pharmacology; Hexuronic Acids - chemistry; Hexuronic Acids - pharmacology; Hypertension - complications; Hypertension - drug therapy; Hypertension - physiopathology; kidney; Kidney Diseases - drug therapy; Kidney Diseases - etiology; Kidney Diseases - pathology; Kidney Diseases - physiopathology; Kidney Glomerulus - drug effects; Kidney Glomerulus - injuries; Kidney Glomerulus - pathology; Male; Molecular Weight; Natriuresis - drug effects; Oligosaccharides - chemistry; Oligosaccharides - pharmacology; Rats; Rats, Inbred Dahl; salt-induced hypertension; Sodium Chloride, Dietary - administration & dosage
• ISSN: 1064-1963; 1525-6006
• DOI: 10.3109/10641963.2011.618196

Objectives: In this article, the antihypertensive effects of sodium alginate oligosaccharides, enzymatic products of high molecular natural alginate from sea weeds, in Dahl salt-sensitive (Dahl S) rats were investigated. Material and Methods: Dahl S rats fed a high-salt (4% NaCl) diet were treated with sodium alginate oligosaccharides (4% or 8% w/w) for 7 weeks. Systolic blood pressure (SBP) was measured by the tail-cuff method, and hypertensive cardiovascular benefits and kidney damage were assessed. Glomerular function and morphological sclerosis were determined. Results: SBP increased in an age-dependent manner in the untreated Dahl S rats. Sodium alginate oligosaccharide treatment attenuated the increase in SBP in a dose-dependent manner. The heart and aortic walls weighed less in the rats treated with sodium alginate oligosaccharides than in the untreated rats. The SBP reduction was associated with a decrease in urinary protein excretion and an increase in the creatinine clearance rate. Sodium alginate oligosaccharides significantly attenuated hypertensive glomerular sclerosis and arterial injury in the kidney. Fractional excretion of sodium (FENa) decreased in low-salt Dahl S rats and increased with a salt challenge. The alginate oligosaccharides decreased FENa in high-salt Dahl S rats. Conclusions: The results of this study suggest that sodium alginate oligosaccharides attenuate salt-induced hypertension in Dahl S rats. This reduction is associated with decreases in cardiovascular and renal damage.