Light White Oils Exhibit Low Tissue Accumulation Potential and Minimal Toxicity in F344 Rats

Female F344 rats were fed diets containing 0.02%, 0.2%, or 2.0% white mineral oil for 90 days. There were no gross or microscopic differences in target organs at the 0.02% level. In the higher-dose groups, relative liver and mesenteric lymph node (MLN) weights were increased, and MLN inflammation wa...

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Bibliographic Details
Published in:International journal of toxicology 2012-03, Vol.31 (2), p.175-183
Main Authors: McKee, Richard H., Drummond, John G., Freeman, James J., Letinski, Daniel J., Miller, Mary Jo
Format: Article
Language:English
Subjects:
Animals
Female
Granuloma - chemically induced
Hydrocarbons - metabolism
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Liver - drug effects
Liver - metabolism
Liver - pathology
Lymph Nodes - drug effects
Lymph Nodes - metabolism
Lymph Nodes - pathology
Mineral Oil - pharmacokinetics
Mineral Oil - toxicity
Molecular Weight
Organ Size - drug effects
Rats
Rats, Inbred F344
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Summary:Female F344 rats were fed diets containing 0.02%, 0.2%, or 2.0% white mineral oil for 90 days. There were no gross or microscopic differences in target organs at the 0.02% level. In the higher-dose groups, relative liver and mesenteric lymph node (MLN) weights were increased, and MLN inflammation was observed. At the 2% level, there was very limited evidence of microgranuloma formation in the liver but at a lower incidence and at lesser severity than has been reported in studies of C22 -C25 oils. Analysis of liver extracts from treated rats revealed that C15 -C20 constituents were underrepresented by comparison to their corresponding concentrations in the test oil. These results provide evidence that although hydrocarbons with carbon numbers
ISSN:1091-5818
1092-874X
DOI:10.1177/1091581811432940