Synthesis and characterization of bovine serum albumin-coated nanocapsules loaded with indocyanine green as potential multifunctional nanoconstructs

We have synthesized and characterized bovine serum albumin (BSA)‐coated polymeric nanocapsules (NCs) loaded with indocyanine green (ICG), an FDA‐approved near infrared chromophore. Poly(allylamine) hydrochloride was electrostatically crosslinked with phosphate anions to form nanoconstructs encapsula...

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Bibliographic Details
Published in:Biotechnology progress 2012-03, Vol.28 (2), p.533-539
Main Authors: Jung, Bongsu, Anvari, Bahman
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Cell Line
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
drug delivery
Drug Delivery Systems - instrumentation
Fundamental and applied biological sciences. Psychology
Humans
Indocyanine Green - chemistry
Nanocapsules - chemistry
nanoparticles
optical imaging
Particle Size
phototherapy
Serum Albumin, Bovine - chemistry
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Summary:We have synthesized and characterized bovine serum albumin (BSA)‐coated polymeric nanocapsules (NCs) loaded with indocyanine green (ICG), an FDA‐approved near infrared chromophore. Poly(allylamine) hydrochloride was electrostatically crosslinked with phosphate anions to form nanoconstructs encapsulating ICG. BSA was conjugated onto the polymeric NCs via glutaraldehyde. BSA‐coated ICG‐containing nanocapsules (BSA‐ICG NCs) were characterized by FTIR and optical spectroscopy, SEM, and zeta‐potential measurements. Using normal human endocervical epithelial cells, we demonstrate the effectiveness of BSA‐ICG NCs for intracellular optical imaging in vitro. These nanoconstructs may potentially serve as a multifunctional platform for combined optical imaging, phototherapy, and drug delivery. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2012
ISSN:8756-7938
1520-6033
DOI:10.1002/btpr.732