Congeneric Lantibiotics from Ribosomal In Vivo Peptide Synthesis with Noncanonical Amino Acids

Expanded repetoire: Synthetic amino acids translated into propeptides dramatically increase the chemical diversity of the two‐component lantibiotic lichenicidin. This opens new routes towards novel and unique peptide antibiotic sequences, which could display features important for medical applicatio...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-01, Vol.51 (2), p.415-418
Main Authors: Oldach, Florian, Al Toma, Rashed, Kuthning, Anja, Caetano, Tânia, Mendo, Sónia, Budisa, Nediljko, Süssmuth, Roderich D.
Format: Article
Language:English
Subjects:
Amino Acids - chemistry
Amino Acids - genetics
Amino Acids - metabolism
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - metabolism
Bacillus - chemistry
Bacillus - genetics
Bacillus - metabolism
Bacteriocins - chemistry
Bacteriocins - genetics
Bacteriocins - metabolism
Cloning, Molecular
Escherichia coli - genetics
Escherichia coli - metabolism
Gene Expression
in vivo peptide synthesis
lantibiotics
lichenicidin
Models, Molecular
noncanonical amino acid
peptide antibiotics
Protein Processing, Post-Translational
Ribosomes - genetics
Ribosomes - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Expanded repetoire: Synthetic amino acids translated into propeptides dramatically increase the chemical diversity of the two‐component lantibiotic lichenicidin. This opens new routes towards novel and unique peptide antibiotic sequences, which could display features important for medical applications.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106154