Determination of Contaminants in Beer Using LC-MS/MS and ICP-MS

The German Beer Purity Law of 1516 makes beer one of the best-analyzed food products with the highest standards regarding quality, freshness, appearance, and flavor. According to this law, beer is allowed to contain hops, malt, yeast, and water as ingredients. Of course, beer also contains major B v...

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Bibliographic Details
Published in:LC GC North America 2016-10, p.14
Main Authors: Oppermann, Uwe, Grüning, Anja, Fromentoux, Ludivine, Knoop, Jan
Format: Article
Language:English
Subjects:
Acids
Alcoholic beverages
Beer
Beverages
Breweries
Calibration
Chromatography
Copper
Heavy metals
Hops
Mass spectrometry
Metabolites
Methods
Pesticides
Polyethylene terephthalate
Quality control
Quality standards
Raw materials
Scientific imaging
Trace elements
Yeast
Zinc
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Summary:The German Beer Purity Law of 1516 makes beer one of the best-analyzed food products with the highest standards regarding quality, freshness, appearance, and flavor. According to this law, beer is allowed to contain hops, malt, yeast, and water as ingredients. Of course, beer also contains major B vitamins, bitter substances, as well as minerals and trace elements (such as Ca, Na, Mg, and Zn) that are important for human nutrition. However, undesirable substances such as pesticides and heavy metals (for instance. Cd, Pb, Hg, Sb, and As) can be found in beer as well, mostly as contaminants in brewing water and grains. In particular, the herbicide glyphosate has to be monitored carefully since it is discussed as a possible carcinogen. The chromatography of glyphosate is challenging because of its high polarity. A well-established method including a derivatization step with 9-fluorenylmethyl chloroformate (FMOC) followed by liquid chromatographytandem mass spectrometry (LC-MS/MS) analysis is time-consuming and also susceptible to errors. A sample pretreatment without derivatization is desirable because it is faster and cheaper. The use of a triple-quadrupole mass spectrometer optimizes the analytical procedure and establishes a routine method for the analysis of glyphosate in beer. For the determination of elements present in low concentrations, such as As, Se, Pb, Cd, and Zn, inductively coupled plasma-mass spectrometry (ICP-MS) is applied.
ISSN:1527-5949
1939-1889