Development of an improved fluidization segregation tester for use with pharmaceutical powders

This article describes the design and development of a material-sparing fluidization segregation tester for use with pharmaceutical powders. This tester offers several improvements over the current ASTM standardized test practice. Less than 20 mL of material is required to characterize the fluidizat...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical Technology 2006-12, Vol.30 (12), p.54-64
Main Authors: HEDDEN, David B, BRONE, Dean L, CLEMENT, Scott, MCCALL, Mike, OLSOFSKY, Angela, PATEL, Phenil J, PRESCOTT, James, HANCOCK, Bruno C
Format: Magazinearticle
Language:English
Subjects:
Analysis
Biological and medical sciences
Design
Design specifications
Fluidization
General pharmacology
Materials selection
Medical equipment
Medical sciences
Pharmaceutical research
Pharmaceutical technology. Pharmaceutical industry
Pharmaceuticals
Pharmacology. Drug treatments
Powders (Pharmacy)
Product development
Reproducibility
Research methodology
Test equipment
Test methods
Testing
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This article describes the design and development of a material-sparing fluidization segregation tester for use with pharmaceutical powders. This tester offers several improvements over the current ASTM standardized test practice. Less than 20 mL of material is required to characterize the fluidization segregation potential of a sample. Features of the tester include powder containment for potent compounds, in-process monitoring of the fluidization conditions, and sample retrieval without the need for subsampling or riffling for typical analyses. [PUBLICATION ABSTRACT]
ISSN:1543-2521
2150-7376