Sampling Flexibility for Raman Spectroscopy

Key Issues: * Sampling flexibility of Raman enables in-process analysis of solids, turbid media, liquids, and gases * Large volumetric Raman provide representative sampling of heterogenous solids Raman spectroscopy is an analysis technique that provides a "molecular fingerprint" of the sam...

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Bibliographic Details
Published in:Spectroscopy 2018-02, p.16-16
Main Authors: Esmonde-White, Karen A, Gilliam, Sean, Strachan, David, Lewis, Ian R
Format: Magazinearticle
Language:English
Subjects:
Analytical methods
Fiber optics
Flexibility
Laboratories
Measurement techniques
Pharmaceuticals
Raman spectroscopy
Online Access:Get full text
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Summary:Key Issues: * Sampling flexibility of Raman enables in-process analysis of solids, turbid media, liquids, and gases * Large volumetric Raman provide representative sampling of heterogenous solids Raman spectroscopy is an analysis technique that provides a "molecular fingerprint" of the sample, enabling analysis of chemical composition and molecular structure without sample preparation. In situ real-time analysis, compatibility with aqueous systems, nondestructive nature, and high chemical specificity means that a Raman-analyzed sample is representative of the process. Because Raman is a nondestructive technique, the same sample measured by Raman can also be measured by other analytical techniques. Examples of processes benefiting from Raman spectroscopy include: * Pharmaceutical formulations: blending, granulation, coating, drying, tableting, content uniformity * Pharmaceutical API: reaction chemistry, yield, polymorph form identification, crystallization * Polymer: polymerization blending, extrusion monitoring, crystallinity, density, copolymers * Bioprocessing: cell culture, fermentation Kaiser Optical Systems 371 Parkland Plaza, Ann Arbor, MI 48103 tel.
ISSN:0887-6703
1939-1900