The Effect of Preconception Vitamin D Levels on Live Birth and Pregnancy Loss

To further understand the relationship of preconception vitamin D levels with live birth and pregnancy loss, Mumford et al performed a secondary analysis on the prospective cohort, block-randomized, double-blind, placebo- controlled Effects of Aspirin in Gestation and Reproduction (EAGeR) trial.2 Th...

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Bibliographic Details
Published in:Integrative medicine alert 2019-04, Vol.22 (4)
Main Author: Pantuso, Traci
Format: Article
Language:English
Subjects:
Age
Births
In vitro fertilization
Infertility
Menstruation
Metabolites
Pregnancy
Reproductive system
Studies
Ultrasonic imaging
Urine
Vitamin D
Vitamin deficiency
Womens health
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Summary:To further understand the relationship of preconception vitamin D levels with live birth and pregnancy loss, Mumford et al performed a secondary analysis on the prospective cohort, block-randomized, double-blind, placebo- controlled Effects of Aspirin in Gestation and Reproduction (EAGeR) trial.2 The authors of the EAGeR trial assessed the effect of daily low-dose aspirin on reproductive outcomes in women with a history of pregnancy loss, but the researchers collected other information from the cohort. Secondary analyses do not always control for important variables, such as genetic variation in key proteins involved in vitamin D metabolism that affect circulating concentrations of vitamin D metabolites.4 The cutoffs for vitamin D sufficiency and insufficiency were determined by the Endocrine Society and may not be relevant to levels needed for healthy reproductive function.3 The cutoffs for vitamin D sufficiency and insufficiency were based on studies investigating the association with bone health and not with reproductive immune function.1,3,4 Also, other studies have demonstrated that the relationship between vitamin D serum levels and bone indices are weaker than previously thought and not consistent across races.3 In addition, there are increasing concerns that vitamin D levels measured by 25-OH serum levels may not be the best indicator of vitamin D status. Since evidence demonstrating that serum vitamin D levels may not be the best indicator of vitamin D status, particularly in non-white populations, ordering vitamin D serum levels and treating patients with vitamin D supplementation for indications other than bone health may be premature.
ISSN:2325-2812
2325-2820