Exercise-Induced Brain Excitability Changes in Progressive Multiple Sclerosis: A Pilot Study

Even a single bout of aerobic exercise (AE) enhances corticospinal excitability (CSE), a biomarker of neuroplasticity. Because neurodegeneration limits capacity for neuroplasticity, it is not clear whether AE would induce CSE changes in people with progressive multiple sclerosis (MS). People with pr...

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Bibliographic Details
Published in:Journal of neurologic physical therapy 2020-04, Vol.44 (2), p.132-144
Main Authors: Chaves, Arthur R., Devasahayam, Augustine J., Kelly, Liam P., Pretty, Ryan W., Ploughman, Michelle
Format: Article
Language:English
Subjects:
Adult
Aged
Brain - physiopathology
Evoked Potentials, Motor - physiology
Exercise
Exercise - physiology
Exercise Test
Female
Humans
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis - physiopathology
Neuronal Plasticity - physiology
Physical fitness
Pilot Projects
Transcranial Magnetic Stimulation
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Summary:Even a single bout of aerobic exercise (AE) enhances corticospinal excitability (CSE), a biomarker of neuroplasticity. Because neurodegeneration limits capacity for neuroplasticity, it is not clear whether AE would induce CSE changes in people with progressive multiple sclerosis (MS). People with progressive MS (n = 10) requiring ambulatory assistive devices completed a graded maximal exercise test. Dual-energy x-ray absorptiometry was used to quantify body fat and lean mass. Before and following one 40-minute AE session using body weight-supported (
ISSN:1557-0576
1557-0584
DOI:10.1097/NPT.0000000000000308