Antifungal stewardship: Core elements to success

Invasive fungal infection mortality often exceeds 50% despite antifungal therapy, especially when occurring in immunosuppressed patients. Because most antifungals have complex pharmacokinetic profiles with many drug-drug or drug-food interactions, dosing regimens or drugs may need to be altered to o...

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Bibliographic Details
Published in:Infectious Disease News 2021-07, Vol.34 (7), p.7-7
Main Author: Brock, Jeff
Format: Article
Language:English
Subjects:
Antibiotics
Antifungal agents
Antimicrobial agents
Clinical outcomes
Drug interactions
Drug resistance
Drug stores
Fungal infections
Infectious diseases
Mortality
Patients
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Summary:Invasive fungal infection mortality often exceeds 50% despite antifungal therapy, especially when occurring in immunosuppressed patients. Because most antifungals have complex pharmacokinetic profiles with many drug-drug or drug-food interactions, dosing regimens or drugs may need to be altered to optimize therapy to help improve patient outcomes. According to the CDC, approximately 7% of Candida species isolated from blood cultures are resistant to fluconazole. Implementation of prescribing restrictions or preauthorization requirements is another effective way to limit unnecessary antifungal use, but this approach could have an unintended consequence on patient outcomes if optimal treatment is delayed. [...]monitoring patient outcomes is recommended if antifungal restrictions are in place.
ISSN:1056-9251