Evaluating the Impact of Fatty Alcohols on Permeation of Clotrimazole from Topical Creams

The permeation studies revealed an interesting correlation between the physicochemical characteristics of the fatty alcohols and the rate of delivery of clotrimazole. High-performance liquid chromatography (HPLC)-grade solvents, like methanol and ethanol, were purchased from Fisher Chemicals (Pittsb...

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Bibliographic Details
Published in:Pharmaceutical Technology 2020-12, Vol.44 (12), p.24-31
Main Authors: Bhide, Supriya, Panda, Apoorva, Rangappa, S, Shettar, Abhishek, Repka, M A, Prado, Rosa Maria Badani, Kundu, S, Richardson, Norman, Murthy, S Narasimha
Format: Magazinearticle
Language:English
Subjects:
Alcohol
Aluminum
Cadavers
Drug dosages
Microscopy
Skin
Viscosity
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Summary:The permeation studies revealed an interesting correlation between the physicochemical characteristics of the fatty alcohols and the rate of delivery of clotrimazole. High-performance liquid chromatography (HPLC)-grade solvents, like methanol and ethanol, were purchased from Fisher Chemicals (Pittsburgh, PA). To assess the impact of different quality attributes on the permeation of drugs from topical formulations at infinite dose conditions, different tests such as pH, globule size distribution, viscosity at a low shear rate, and phase distribution of drugs, were performed and evaluated. pH measurement. During the in-vitro permeation testing (IVPT) studies, the samples were withdrawn The drug distribution in different phases is one of the major factors that could influence transdermal absorption. from the receiver compartment at the time points of 2 h, 4 h, 8 h, 10 h, 12 h, and replaced by equal quantities of fresh medium.
ISSN:1543-2521
2150-7376