CLINICAL EFFICACY OF SULBACTAM/AMPICILLIN IN COMPARISON WITH CEFOTIAM IN THE TREATMENT OF ELDERLY PATIENTS WITH PNEUMONIA

Clinical efficacy and safety of pareteral sulbactam/ampicillin (SBT/ABPC) was compared with cefotiam (CTM) in a randomized clinical trial of pneumonia in the elderly at 13 National Hospitals of Kyushu island. 37 patients received SBT/ABPC 3 g i.v., b.i.d., and 31 patients received CTM 1 g i.v., b.i....

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Bibliographic Details
Published in:Japanese journal of antibiotics 1998/12/25, Vol.51(12), pp.746-758
Main Authors: ISHIBASHI, TSUNEO, HARADA, YASUKO, TAKAMOTO, MASAHIRO, IWANAGA, TOMOAKI, KISHIKAWA, REIKO, MAKIE, TOSHIO, TSURUTANI, HIDETO, HIROTA, NOBUO, FURUNO, TAKASHI, OE, TOSHIYUKI, INUYAMA, MASAHITO, CHIFU, SADAMU, TANAKA, HIRONORI, TAKEMURA, HIROMU, NAKATOMI, MASAO, OTSU, TATSUYA, FUKUSHIMA, KAZUO, HONDA, IZUMI, MAEDA, JUNKO, SHIRAKAWA, TAEKO, OHMURA, HARUTAKA, NAOE, HIROAKI, EBIHARA, MOMOKO, SUGIYAMA, MIDORI, SHIMAZU, KAZUYASU, KISANUKI, KOHICHI, MITSUNO, TOSHIHIDE, HIRAOKA, TAKESUKE, TSUMORI, YOKO, MATSUURA, YUKA, NAMBA, KOJI, FUKUNAGA, HIDETOMO, UENO, YOSHIHISA, MATSUKIZONO, KAZUYA, MATSUYAMA, WATARU, MIZOGUCHI, AKIRA, IWAMI, FUMIYUKI, KYAN, KUNIO, NAKAMOTO, ATSUSHI, KUBA, MUTSUO, GENKA, KEIICHIRO
Format: Article
Language:Japanese
Subjects:
Aged
Aged, 80 and over
Alanine Transaminase - blood
Ampicillin - administration & dosage
Ampicillin - adverse effects
Aspartate Aminotransferases - blood
Cefotiam - administration & dosage
Cefotiam - adverse effects
Cephalosporins - administration & dosage
Cephalosporins - adverse effects
Drug Evaluation
Drug Therapy, Combination - administration & dosage
Drug Therapy, Combination - adverse effects
Female
Humans
Infusions, Intravenous
Male
Pneumonia, Bacterial - drug therapy
Sulbactam - administration & dosage
Sulbactam - adverse effects
Treatment Outcome
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Summary:Clinical efficacy and safety of pareteral sulbactam/ampicillin (SBT/ABPC) was compared with cefotiam (CTM) in a randomized clinical trial of pneumonia in the elderly at 13 National Hospitals of Kyushu island. 37 patients received SBT/ABPC 3 g i.v., b.i.d., and 31 patients received CTM 1 g i.v., b.i.d. for 7 to 14 days. 1. 68 patients (37 for SBT/ABPC and 31 for CTM) were evaluated for safety. No statistical differences were noted in the patients' backgrounds of either group. 2. The clinical efficacy of SBT/ABPC was 96.3% (26/27 cases) while CTM was 75.2% (17/23 cases). This was found to be statistically significant (Fisher's exact test: p
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.51.746