Non-invasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements

Measurements of the tissue concentrations of two chemotherapy agents have been made in vivo on an animal tumour model. The method used is based on elastic scattering spectroscopy (ESS) and utilizes a fibre-optic probe spectroscopic system. A broadband light source is used to acquire data over a broa...

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Bibliographic Details
Published in:Physics in medicine & biology 1999-05, Vol.44 (5), p.1397-1417
Main Authors: Mourant, Judith R, Johnson, Tamara M, Los, Gerrit, Bigio, Irving J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - analysis
Antineoplastic Agents - pharmacokinetics
Biological and medical sciences
Biophysical Phenomena
Biophysics
Chromatography, High Pressure Liquid
Doxorubicin - analysis
Doxorubicin - pharmacokinetics
Evaluation Studies as Topic
Fiber Optic Technology - instrumentation
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Mice
Mice, Nude
Miscellaneous. Technology
Monte Carlo Method
Neoplasms, Experimental - metabolism
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phantoms, Imaging
Photochemotherapy
Photosensitizing Agents - analysis
Photosensitizing Agents - pharmacokinetics
Scattering, Radiation
Spectrum Analysis - instrumentation
Spectrum Analysis - methods
Tissue Distribution
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Summary:Measurements of the tissue concentrations of two chemotherapy agents have been made in vivo on an animal tumour model. The method used is based on elastic scattering spectroscopy (ESS) and utilizes a fibre-optic probe spectroscopic system. A broadband light source is used to acquire data over a broad range of wavelengths and, therefore, to facilitate the separation of absorptions from various chromophores. The results of the work include measurements of the time course of the drug concentrations as well as a comparison of the optical measurements with high performance liquid chromatography (HPLC) analysis of the drug concentrations at the time of sacrifice. It is found that the optical measurements correlate linearly with HPLC measurements, but give lower absolute values.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/44/5/322