Differential lung mechanics are genetically determined in inbred murine strains

• Published in: Journal of applied physiology (1985) 1999-06, Vol.86 (6), p.1764-1769
• Main Authors: Tankersley, Clarke G, Rabold, Richard, Mitzner, Wayne
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Cardiorespiratory control. Arterial mecano- and chemoreceptor; Fundamental and applied biological sciences. Psychology; Genetics; Lung - physiology; Lung Volume Measurements; Lungs; Male; Mice; Mice, Inbred A; Mice, Inbred C3H; Mice, Inbred C57BL; Phenotype; Plethysmography; Residual Volume; Respiratory Mechanics - genetics; Total Lung Capacity; Vertebrates: respiratory system
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1999.86.6.1764

Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205 Genetic determinants of lung structure and function have been demonstrated by differential phenotypes among inbred mice strains. For example, previous studies have reported phenotypic variation in baseline ventilatory measurements of standard inbred murine strains as well as segregant and nonsegregant offspring of C3H/HeJ (C3) and C57BL/6J (B6) progenitors. One purpose of the present study is to test the hypothesis that a genetic basis for differential baseline breathing pattern is due to variation in lung mechanical properties. Quasi-static pressure-volume curves were performed on standard and recombinant inbred strains to explore the interactive role of lung mechanics in determination of functional baseline ventilatory outcomes. At airway pressures between 0 and 30 cmH 2 O, lung volumes are significantly ( P