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Ultrastructural muscle damage in young vs. older men after high-volume, heavy-resistance strength training
1 Department of Kinesiology, University of Maryland College Park, College Park, 20742; 2 Department of Physical Therapy, University of Maryland Eastern Shore, Princess Anne, 21853; and 3 Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 This study assessed ultras...
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| Published in: | Journal of applied physiology (1985) 1999-06, Vol.86 (6), p.1833-1840 |
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| Main Authors: | , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c437t-9b37a4dab3f51c27cbee9ab10194e573002f43f9b95ab533f6ffc7348ee93af43 |
| container_end_page | 1840 |
| container_issue | 6 |
| container_start_page | 1833 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 86 |
| creator | Roth, Stephen M Martel, Gregory F Ivey, Frederick M Lemmer, Jeffrey T Tracy, Brian L Hurlbut, Diane E Metter, E. Jeffrey Hurley, Ben F Rogers, Marc A |
| description | 1 Department of Kinesiology,
University of Maryland College Park, College Park, 20742;
2 Department of Physical Therapy,
University of Maryland Eastern Shore, Princess Anne, 21853; and
3 Gerontology Research Center,
National Institute on Aging, Baltimore, Maryland 21224
This study assessed ultrastructural
muscle damage in young (20-30 yr old) vs. older (65-75 yr
old) men after heavy-resistance strength training (HRST). Seven young
and eight older subjects completed 9 wk of unilateral leg extension
HRST. Five sets of 5-20 repetitions were performed 3 days/wk with
variable resistance designed to subject the muscle to near-maximal
loads during every repetition. Biopsies were taken from the vastus
lateralis of both legs, and muscle damage was quantified via electron
microscopy. Training resulted in a 27% strength increase in both
groups ( P |
| doi_str_mv | 10.1152/jappl.1999.86.6.1833 |
| format | article |
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University of Maryland College Park, College Park, 20742;
2 Department of Physical Therapy,
University of Maryland Eastern Shore, Princess Anne, 21853; and
3 Gerontology Research Center,
National Institute on Aging, Baltimore, Maryland 21224
This study assessed ultrastructural
muscle damage in young (20-30 yr old) vs. older (65-75 yr
old) men after heavy-resistance strength training (HRST). Seven young
and eight older subjects completed 9 wk of unilateral leg extension
HRST. Five sets of 5-20 repetitions were performed 3 days/wk with
variable resistance designed to subject the muscle to near-maximal
loads during every repetition. Biopsies were taken from the vastus
lateralis of both legs, and muscle damage was quantified via electron
microscopy. Training resulted in a 27% strength increase in both
groups ( P < 0.05). In biopsies
before training in the trained leg and in all biopsies from untrained
leg, 0-3% of muscle fibers exhibited muscle damage in both groups
( P = not significant). After HRST, 7 and 6% of fibers in the trained leg exhibited damage in the young and
older men, respectively ( P < 0.05, no significant group differences). Myofibrillar damage was primarily
focal, confined to one to two sarcomeres. Young and older men appear to
exhibit similar levels of muscle damage at baseline and after chronic HRST.
aging; muscle fiber hyper-contraction; muscle injury; regeneration; resistance training</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1999.86.6.1833</identifier><identifier>PMID: 10368346</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Actin Cytoskeleton - ultrastructure ; Adult ; Aged ; Aging - physiology ; Biological and medical sciences ; Body Composition - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Men ; Microscopy, Electron ; Muscle Fibers, Skeletal - ultrastructure ; Muscle, Skeletal - chemistry ; Muscle, Skeletal - physiology ; Muscle, Skeletal - ultrastructure ; Muscular system ; Sports training ; Striated muscle. Tendons ; Tissue Fixation ; Vertebrates: osteoarticular system, musculoskeletal system ; Weight Lifting - physiology</subject><ispartof>Journal of applied physiology (1985), 1999-06, Vol.86 (6), p.1833-1840</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Physiological Society Jun 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-9b37a4dab3f51c27cbee9ab10194e573002f43f9b95ab533f6ffc7348ee93af43</citedby><cites>FETCH-LOGICAL-c437t-9b37a4dab3f51c27cbee9ab10194e573002f43f9b95ab533f6ffc7348ee93af43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1861075$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10368346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roth, Stephen M</creatorcontrib><creatorcontrib>Martel, Gregory F</creatorcontrib><creatorcontrib>Ivey, Frederick M</creatorcontrib><creatorcontrib>Lemmer, Jeffrey T</creatorcontrib><creatorcontrib>Tracy, Brian L</creatorcontrib><creatorcontrib>Hurlbut, Diane E</creatorcontrib><creatorcontrib>Metter, E. Jeffrey</creatorcontrib><creatorcontrib>Hurley, Ben F</creatorcontrib><creatorcontrib>Rogers, Marc A</creatorcontrib><title>Ultrastructural muscle damage in young vs. older men after high-volume, heavy-resistance strength training</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Department of Kinesiology,
University of Maryland College Park, College Park, 20742;
2 Department of Physical Therapy,
University of Maryland Eastern Shore, Princess Anne, 21853; and
3 Gerontology Research Center,
National Institute on Aging, Baltimore, Maryland 21224
This study assessed ultrastructural
muscle damage in young (20-30 yr old) vs. older (65-75 yr
old) men after heavy-resistance strength training (HRST). Seven young
and eight older subjects completed 9 wk of unilateral leg extension
HRST. Five sets of 5-20 repetitions were performed 3 days/wk with
variable resistance designed to subject the muscle to near-maximal
loads during every repetition. Biopsies were taken from the vastus
lateralis of both legs, and muscle damage was quantified via electron
microscopy. Training resulted in a 27% strength increase in both
groups ( P < 0.05). In biopsies
before training in the trained leg and in all biopsies from untrained
leg, 0-3% of muscle fibers exhibited muscle damage in both groups
( P = not significant). After HRST, 7 and 6% of fibers in the trained leg exhibited damage in the young and
older men, respectively ( P < 0.05, no significant group differences). Myofibrillar damage was primarily
focal, confined to one to two sarcomeres. Young and older men appear to
exhibit similar levels of muscle damage at baseline and after chronic HRST.
aging; muscle fiber hyper-contraction; muscle injury; regeneration; resistance training</description><subject>Actin Cytoskeleton - ultrastructure</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Body Composition - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Men</subject><subject>Microscopy, Electron</subject><subject>Muscle Fibers, Skeletal - ultrastructure</subject><subject>Muscle, Skeletal - chemistry</subject><subject>Muscle, Skeletal - physiology</subject><subject>Muscle, Skeletal - ultrastructure</subject><subject>Muscular system</subject><subject>Sports training</subject><subject>Striated muscle. Tendons</subject><subject>Tissue Fixation</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><subject>Weight Lifting - physiology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp1kV-L1TAQxYMo7nX1G4gEEfHB1qRJ2vRRFleFBV92n0OaTnpzSf-YtHfttzf1XtxFMC8TmN85M8xB6DUlOaWi-HTQ0-RzWtd1Lsu8zKlk7AnapVaR0ZLQp2gnK0GySsjqAr2I8UAI5VzQ5-iCElZKxssdOtz5Oeg4h8XMS9Ae90s0HnCre90BdgNex2Xo8DHmePQtBNzDgLWd02_vun12HP3Sw0e8B31cswDRxVkPBnDyhKGb9zj5u8EN3Uv0zGof4dW5XqK76y-3V9-ymx9fv199vskMZ9Wc1Q2rNG91w6ygpqhMA1DrhhJacxAVI6SwnNm6qYVuBGO2tNZUjMuEMZ1al-j9yXcK488F4qx6Fw14rwcYl6iopIwJThL49h_wMC5hSLupIj1SUykTxE-QCWOMAayagut1WBUlagtC_QlCbUEoWapSbUEk2Zuz99L00D4SnS6fgHdnQEejvQ3paC4-cLKkpBIP47dj37sAatqv0Y1-7FZ1vXh_C7_mbYW_o9XU2iT78H9Zoh9t-huYt7UY</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Roth, Stephen M</creator><creator>Martel, Gregory F</creator><creator>Ivey, Frederick M</creator><creator>Lemmer, Jeffrey T</creator><creator>Tracy, Brian L</creator><creator>Hurlbut, Diane E</creator><creator>Metter, E. 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Jeffrey ; Hurley, Ben F ; Rogers, Marc A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-9b37a4dab3f51c27cbee9ab10194e573002f43f9b95ab533f6ffc7348ee93af43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Actin Cytoskeleton - ultrastructure</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Body Composition - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Men</topic><topic>Microscopy, Electron</topic><topic>Muscle Fibers, Skeletal - ultrastructure</topic><topic>Muscle, Skeletal - chemistry</topic><topic>Muscle, Skeletal - physiology</topic><topic>Muscle, Skeletal - ultrastructure</topic><topic>Muscular system</topic><topic>Sports training</topic><topic>Striated muscle. Tendons</topic><topic>Tissue Fixation</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><topic>Weight Lifting - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roth, Stephen M</creatorcontrib><creatorcontrib>Martel, Gregory F</creatorcontrib><creatorcontrib>Ivey, Frederick M</creatorcontrib><creatorcontrib>Lemmer, Jeffrey T</creatorcontrib><creatorcontrib>Tracy, Brian L</creatorcontrib><creatorcontrib>Hurlbut, Diane E</creatorcontrib><creatorcontrib>Metter, E. 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Jeffrey</au><au>Hurley, Ben F</au><au>Rogers, Marc A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrastructural muscle damage in young vs. older men after high-volume, heavy-resistance strength training</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>86</volume><issue>6</issue><spage>1833</spage><epage>1840</epage><pages>1833-1840</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Department of Kinesiology,
University of Maryland College Park, College Park, 20742;
2 Department of Physical Therapy,
University of Maryland Eastern Shore, Princess Anne, 21853; and
3 Gerontology Research Center,
National Institute on Aging, Baltimore, Maryland 21224
This study assessed ultrastructural
muscle damage in young (20-30 yr old) vs. older (65-75 yr
old) men after heavy-resistance strength training (HRST). Seven young
and eight older subjects completed 9 wk of unilateral leg extension
HRST. Five sets of 5-20 repetitions were performed 3 days/wk with
variable resistance designed to subject the muscle to near-maximal
loads during every repetition. Biopsies were taken from the vastus
lateralis of both legs, and muscle damage was quantified via electron
microscopy. Training resulted in a 27% strength increase in both
groups ( P < 0.05). In biopsies
before training in the trained leg and in all biopsies from untrained
leg, 0-3% of muscle fibers exhibited muscle damage in both groups
( P = not significant). After HRST, 7 and 6% of fibers in the trained leg exhibited damage in the young and
older men, respectively ( P < 0.05, no significant group differences). Myofibrillar damage was primarily
focal, confined to one to two sarcomeres. Young and older men appear to
exhibit similar levels of muscle damage at baseline and after chronic HRST.
aging; muscle fiber hyper-contraction; muscle injury; regeneration; resistance training</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>10368346</pmid><doi>10.1152/jappl.1999.86.6.1833</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1999-06, Vol.86 (6), p.1833-1840 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pubmed_primary_10368346 |
| source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
| subjects | Actin Cytoskeleton - ultrastructure Adult Aged Aging - physiology Biological and medical sciences Body Composition - physiology Fundamental and applied biological sciences. Psychology Humans Male Men Microscopy, Electron Muscle Fibers, Skeletal - ultrastructure Muscle, Skeletal - chemistry Muscle, Skeletal - physiology Muscle, Skeletal - ultrastructure Muscular system Sports training Striated muscle. Tendons Tissue Fixation Vertebrates: osteoarticular system, musculoskeletal system Weight Lifting - physiology |
| title | Ultrastructural muscle damage in young vs. older men after high-volume, heavy-resistance strength training |
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