Age and renal prostaglandin inhibition during exercise and heat stress

• Published in: Journal of applied physiology (1985) 1999-06, Vol.86 (6), p.1936-1943
• Main Authors: Farquhar, W. B, Kenney, W. L
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aging; Aging - physiology; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Biological and medical sciences; Dinoprostone - urine; Double-Blind Method; Drugs; Exercise; Exercise - physiology; Female; Fundamental and applied biological sciences. Psychology; Glomerular Filtration Rate - physiology; Heat Stress Disorders - physiopathology; Humans; Ibuprofen - pharmacology; Kidney - drug effects; Kidney - metabolism; Kidneys; Middle Aged; Prostaglandin Antagonists - pharmacology; Renal Circulation - drug effects; Sodium - urine; Vertebrates: urinary system
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1999.86.6.1936

Noll Physiological Research Center, Pennsylvania State University, University Park, Pennsylvania 16802-6900 Aging is associated with a number of physiological changes that may cause the kidney to rely to a greater extent on vasodilatory PGs for normal functioning. Acute exercise has been shown to cause renal vasoconstriction that may be partially buffered by vasodilatory PGs. To determine the relative importance of renal PGs during exercise in older adults, we compared the renal effects of the PG inhibitor ibuprofen (1.2 g/day for 3 days) vs. a placebo control in a cohort of eight younger (24 ± 2 yr) and eight older (64 ±   2 yr) women during treadmill exercise (~57% maximal oxygen consumption) in the heat (36°C). This over-the-counter dose of ibuprofen reduced renal PG (i.e., PGE 2 ) excretion by 47% ( P