Monitoring of brain metabolism during aneurysm surgery using microdialysis and brain multiparameter sensors

The aim of the study was to monitor brain metabolism during aneurysm clipping using microdialysis and multiparameter sensors, particularly to investigate the effects of temporary clipping of vessels. Microdialysis catheters (n= 10) and Paratrend brain multiparameter (02, C02, pH and temperature) sen...

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Bibliographic Details
Published in:Neurological research (New York) 1999-06, Vol.21 (4), p.352-358
Main Authors: Hutchinson, Peter J., Al-Rawi, Pippa G., O'Connell, Mark T., Gupta, Arun K., Maskell, Lynn B., Hutchinson, David B., Pickard, john D., Kirkpatrick, Peter j.
Format: Article
Language:English
Subjects:
Adult
Aged
Brain - metabolism
Brain - surgery
Equipment Design
Female
Humans
Intracranial Aneurysm - complications
Intracranial Aneurysm - surgery
Male
microdialysis
Microdialysis - methods
Middle Aged
Monitoring, Intraoperative - instrumentation
Oxygen Consumption - physiology
oxygen monitor
subarachnoid hemorrhage
Subarachnoid Hemorrhage - etiology
Subarachnoid Hemorrhage - surgery
Surgical Instruments
Time Factors
Treatment Outcome
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Summary:The aim of the study was to monitor brain metabolism during aneurysm clipping using microdialysis and multiparameter sensors, particularly to investigate the effects of temporary clipping of vessels. Microdialysis catheters (n= 10) and Paratrend brain multiparameter (02, C02, pH and temperature) sensors (n = 15) were inserted into the cerebral cortex via a specially designed triple bolt prior to craniotomy. Baseline brain 02 levels ranging from 15-45 mmHg (2.0-6.0 kPa) and glucose levels from 0.5-3 mmol l~1 were stable during uneventful periods. The mean lactate/pyruvate (L/P) ratio ranged from 32 to 65 (normal < 30), indicating a tendency towards anerobic metabolism in all patients. Overall, short periods of temporary clipping (
ISSN:0161-6412
1743-1328
DOI:10.1080/01616412.1999.11740943