Modulation of oxidative stresses in human aging skin

Oxidative stress (UV irradiation, free radicals) plays a significant role in aging. Coenzyme Q10 (CoQ10) and exogenously applied antioxidants can significantly reduce the formation of oxidative stress with increasing age. In our in vitro and in vivo experiments concerning the parameters of ultraweak...

Full description

Saved in:
Bibliographic Details
Published in:Zeitschrift für Gerontologie und Geriatrie 1999-04, Vol.32 (2), p.83
Main Authors: Blatt, T, Mundt, C, Mummert, C, Maksiuk, T, Wolber, R, Keyhani, R, Schreiner, V, Hoppe, U, Schachtschabel, D O, Stäb, F
Format: Article
Language:ger
Subjects:
Aged
Antioxidants - pharmacology
Cell Survival - drug effects
Cell Survival - physiology
Cell Survival - radiation effects
Coenzymes
Female
Free Radicals - metabolism
Humans
Keratinocytes - drug effects
Keratinocytes - physiology
Keratinocytes - radiation effects
Lipid Peroxidation - drug effects
Lipid Peroxidation - genetics
Lipid Peroxidation - physiology
Male
Skin Aging - drug effects
Skin Aging - physiology
Skin Aging - radiation effects
Ubiquinone - analogs & derivatives
Ubiquinone - pharmacology
Ultraviolet Rays
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oxidative stress (UV irradiation, free radicals) plays a significant role in aging. Coenzyme Q10 (CoQ10) and exogenously applied antioxidants can significantly reduce the formation of oxidative stress with increasing age. In our in vitro and in vivo experiments concerning the parameters of ultraweak photon emission (UPE), intracellular thiol status, mitochondrial membrane potential and cell vitality, we demonstrated a diminished resistance in keratinocytes of old donors against UV irradiation. This reduced epidermal resistance against oxidative stressors, i.e. UV irradiation, can be improved by topical application of CoQ10 and antioxidants like alpha-glucosylrutin (15). Furthermore, our in vivo investigations show that wrinkles around the region of the eyes ("crow feet") could be reduced by long-term application of CoQ10.
ISSN:0948-6704